Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Amyloid beta protein gets bum rap

11.11.2009
Saint Louis U. researchers find low doses of protein linked to Alzheimer's disease enhances memory in healthy

While too much amyloid beta protein in the brain is linked to the development of Alzheimer's disease, not enough of the protein in healthy brains can cause learning problems and forgetfulness, Saint Louis University scientists have found.

The finding could lead to better medications to treat Alzheimer's disease, said John Morley, M.D., director of the division of geriatrics at Saint Louis University and the lead researcher on the study.

"This research is very exciting because it causes us to look at amyloid beta protein in a different way," Morley said.

"After 20 years of research, what we found goes totally against long-standing beliefs about amyloid beta protein. Our results indicate that amyloid beta protein itself isn't the bad guy. The right amount of amyloid beta protein happens to be very important for memory and learning in those who are healthy."

Researchers found that young, healthy mice that received low doses of amyloid beta protein showed improvement in recognizing objects and successfully navigating through a maze. Conversely, mice that received a drug that blocked amyloid beta protein had learning impairment.

"You can't totally wipe out amyloid beta protein. If you do this, you are going to create dementia," Morley said. "In treating Alzheimer's disease, we have to be careful not to lower amyloid beta too much because it will cause as many problems as if you had an excess of amyloid beta protein."

In short, Alzheimer's disease is connected to too much of a good thing. The right amount of amyloid beta in healthy brains actually enhances learning and memory rather than impairs it.

"Excess production of amyloid beta results in memory deficits," Morley said. "Overall, we believe these studies strongly suggest that the physiological role of amyloid beta is to enhance learning and memory.

These findings are important in understanding the optimal design of drugs to treat Alzheimer's disease."

The research, conducted in an animal model, is published in electronic edition of the Sept. 11 edition of the Journal of Alzheimer's Disease.

Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River. The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level. Research at the school seeks new cures and treatments in several key areas: cancer, infectious disease, liver disease, aging and brain disease and heart/lung disease.

Nancy Solomon | EurekAlert!
Further information:
http://www.slu.edu

More articles from Health and Medicine:

nachricht Speed data for the brain’s navigation system
06.12.2016 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Predicting unpredictability: Information theory offers new way to read ice cores

07.12.2016 | Earth Sciences

Sea ice hit record lows in November

07.12.2016 | Earth Sciences

New material could lead to erasable and rewriteable optical chips

07.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>