Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

SNM 2010 Image of the Year: Molecular Imaging Shows Parathyroid Disease in Greater Detail

16.06.2010
Research shows that molecular imaging fusion with high resolution CT anatomy may result in more precise localization of parathyroid lesions

SNM’s 2010 Image of the Year illustrates the potential of hybrid molecular imaging to provide precise information about the location and function of a condition known as “hyperparathyroidism.” Researchers selected this image from more than 1,500 studies presented over the course of four days during SNM’s 57th Annual Meeting in Salt Lake City.


“Each year, SNM chooses an image that exemplifies the most cutting-edge molecular imaging research today, as well as illustrates the potential of molecular imaging to provide physicians with a critical component for the detection and diagnosis of disease,” said Michael M. Graham, Ph.D., M.D., immediate past-president of SNM. “This year’s Image of the Year provides an example of a novel imaging presentation, using a combination of single photon emission computed tomography (SPECT) with high resolution CT angiography, which pinpoints the abnormally functioning parathyroid adenoma and the arteries feeding it. With this information, physicians may be able determine the exact location and size of the abnormal gland and plan minimally invasive surgery that reduces operative time, thus improving patient care.”

The SNM Image of the Year shows the potential of fusion of high-resolution 3D anatomy with functional SPECT images to provide critical information to help physicians to diagnose and treat hyperparathyroidism, an endocrine disease that occurs when the parathyroid glands develop a small adenoma, a benign tumor that produces too much hormone and causes high levels of calcium in the blood. It is usually treated by invasive, exploratory surgery. Using fusion images, physicians can obtain detailed information about the anatomical localization, blood supply and metabolism of the overactive parathyroid adenoma.

In this study, researchers scanned 31 patients with symptoms of primary hyperparathyroidism using a nuclear medicine technique called MIBI, combined with SPECT and multidetector computed tomography (MDCT). Researchers obtained thin-slice multiplanar reconstruction images of the neck using a 64-row MDCT with contrast enhancement. When the enlarged gland was successfully identified, volume-rendered images of the thyroid and parathyroid with feeding arteries were generated. Then, 2- and 3-dimensional fusion images were also obtained using dedicated workstations. The diagnostic value of 3-dimensional SPECT/CT fusion images was compared with those by MIBI SPECT alone and by ultrasound. The study shows that the hybrid molecular imaging technique was more effective than single modality scanning alone.

A total of 34 glands were identified by surgery. SPECT/CT fusion image, MIBI SPECT and ultrasound identified 32 (94%), 27 (79%) and 27 (79%) adenomas, respectively. The fusion imaging technique identified five glands that were missed by ultrasound and MIBI SPECT. The fusion images successfully showed feeding arteries in 29 adenomas. With the use of fusion images for navigation, preliminary results in eight patients showed that operation time is decreased by approximately 82% compared to studies performed without fusion images.

According to the National Institutes of Health, approximately 100,000 Americans develop hyperparathyroidism each year. Women outnumber men two to one, and risk increases with age. In women 60 years and older, two out of 1,000 will develop hyperparathyroidism each year.

Abstract 200: K. Nakada, I. Sakuma, M. Sakurai, K. Noriyasu, Hokko Memorial Hospital, Sapporo, Japan; N. Takada, Kaisei Hospital, Sapporo, Japan; H. Takahashi, Hokkaido University Hospital, Sapporo, Japan. “Clinical Value of Fusion Images of MIBI SPECT and Enhanced MDCT Registered by Workstation in Primary Hyperparathyroidism.” SNM’s 57th Annual Meeting, June 5–9, 2010, Salt Lake City, Utah.

About SNM—Advancing Molecular Imaging and Therapy
SNM is an international scientific and medical organization dedicated to raising public awareness about what molecular imaging is and how it can help provide patients with the best health care possible. SNM members specialize in molecular imaging, a vital element of today’s medical practice that adds an additional dimension to diagnosis, changing the way common and devastating diseases are understood and treated.

SNM’s more than 17,000 members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit http://www.snm.org.

Amy Shaw | EurekAlert!
Further information:
http://www.snm.org

More articles from Medical Engineering:

nachricht Skin patch dissolves 'love handles' in mice
18.09.2017 | Columbia University Medical Center

nachricht Medicine of the future: New microchip technology could be used to track 'smart pills'
13.09.2017 | California Institute of Technology

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Molecular Force Sensors

20.09.2017 | Life Sciences

Producing electricity during flight

20.09.2017 | Power and Electrical Engineering

Tiny lasers from a gallery of whispers

20.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>