"We analyzed the findings of 363 CTC-detected lesions in 244 patients who subsequently underwent optical colonoscopy," said Tyler Prout, MD, lead author of the study. The researchers found that optical colonoscopy verified the presence of polyps in 321 of the 363 CTC-detected instances, making for an overall positive predictive value of 88.4%, he said. In addition, the combined group of polyps with either sessile or pedunculated morphology yielded a matching lesion at optical colonoscopy 91.8% of the time, Dr. Prout added.
"From a practical standpoint, this is very important, because if CTC is to be an effective screening tool it, must not only have a high sensitivity, but have sufficiently high concordance rate at subsequent optical colonoscopy to avoid unnecessary colonoscopies," said Dr. Prout.
Exact polyp size had little effect on the concordance rate, said Dr. Prout. "In our more recent experience, we do nearly as well detecting the smaller 6-7 mm polyps as those that are 1 cm or greater. Moreover, when comparing these results to our earlier experience, we find our positive predictive value at the 6-7mm polyp size threshold to be much improved; now 85%, whereas it was previously just over 50%," said Dr. Prout. "We believe that this finding can be attributed to a combination of factors, some of the most important of which include colonic preparation and method of image analysis. Our colonic preparation includes both fluid and stool tagging. For image analysis, we employ a primary 3D evaluation complemented by focused review of 2D multiplanar reformats for confirmation. This is in contradistinction from many studies that utilize primary 2D interpretation," said Dr. Prout.
The full results of this study will be presented as an electronic exhibit Monday, May 7 through Thursday May 10 during the American Roentgen Ray Society’s annual meeting in Orlando, FL.
Necoya Lightsey | EurekAlert!
A Challenging European Research Project to Develop New Tiny Microscopes
28.03.2017 | Technische Universität Braunschweig
3-D visualization of the pancreas -- new tool in diabetes research
15.03.2017 | Umea University
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences