Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hopkins researchers use diffusion MRI technique to monitor ultrasound uterine fibroid treatment

09.08.2005


Johns Hopkins researchers have, for what is believed to be the first time, used a magnetic resonance imaging (MRI) technique called diffusion-weighted MRI (DWI), a technique that images the movement, or diffusion, of water molecules in tissues, to successfully determine the effectiveness of high-intensity focused ultrasound for treating uterine fibroids. Uterine fibroids are noncancerous tumors that line the uterine wall and can cause intense pain and bleeding. The study appears in the July edition of Radiology.

Ultrasound treatment works by directing focused ultrasound energy that heats the targeted tissue to induce cell damage or death without damaging the surrounding tissue. Because it’s noninvasive, the treatment provides a desirable alternative to conventional surgery and was undergoing clinical trials nationally and was recently given FDA approval.

When fibroids or other tissues are damaged or destroyed by ultrasound treatment, water molecules are trapped within the tissue because the cellular pumps that control the movement of water into or out of cells no longer function properly. By measuring the movement of this water using DWI, the researchers hoped to better gauge the impact of treatment on the fibroids by using a quantitative biophysical parameter called the apparent diffusion coefficient (ADC).

Currently, treatment success is determined using regular MRI with a contrast agent (a dye injected into the patient to enhance the resulting image). However, the image produced during this procedure does not precisely show functional information on the degree of fibroid destruction. Therefore, physicians also rely on questionnaires administered to patients after their fibroid treatment, which often are very subjective and unreliable.

In the study, 14 patients with uterine fibroids received ultrasound treatment and subsequent MR imaging using three different MR techniques: conventional MRI, MRI with contrast material, and DWI MRI. Results showed significantly greater signal intensity on DWI of ultrasound treated fibroids than on the images of untreated fibroids or treated fibroids obtained with the other MR methods. These results were confirmed in the 12 patients who took part in the six-month follow up study. Also observed were differences in the ADC. The DWI technique was able to map the ADC in fibroids, showing lower ADC values in treated fibroids than in surrounding tissue, a measure of restricted cellular water flow due to the ultrasound treatment.

"While these results are preliminary and more research is needed, they strongly suggest that the diffusion-weighted MR technique provides images that show functional changes and the extent of fibroid damage from treatment. DWI may be useful for monitoring the effects of ultrasound treatment on uterine fibroids," says Michael Jacobs, Ph.D., assistant professor of radiology and oncology at the Russell H. Morgan Department of Radiology and Radiological Science at Johns Hopkins. "The results also suggest that this imaging technique may be useful for monitoring other focused ultrasound treatments for lesions in the prostate, and breast, when available." The other co-authors of the study were Hyun "Kevin" Kim, M.D. and Edward Herskovits, M.D., Ph.D. This study was supported in part by grants from the National Institutes of Health.

Gary Stephenson | EurekAlert!
Further information:
http://www.jhmi.edu
http://www.hopkinsmedicine.org/mediaII/RSSinstructions.html

More articles from Medical Engineering:

nachricht Virtual Reality in Medicine: New Opportunities for Diagnostics and Surgical Planning
07.12.2016 | Universität Basel

nachricht 3-D printed kidney phantoms aid nuclear medicine dosing calibration
06.12.2016 | Society of Nuclear Medicine

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>