Each year, hundreds of thousands of people suffer medical complications from hypodermic needles that penetrate too far under their skin. A new device developed by MIT engineers and colleagues aims to prevent this from happening by keeping needles on target.
The device, which is purely mechanical, is based on concepts borrowed from the oil industry. It involves a hollow S-shaped needle containing a filament that acts as a guide wire. When a physician pushes the device against a tissue, she is actually applying force only to the filament, not the needle itself, thanks to a special clutch.
When the filament, which moves through the tip of the needle, encounters resistance from a firm tissue, it begins to buckle within the S-shaped tube. Due to the combined buckling and interactions with the walls of the tube, the filament locks into place "and the needle and wire advance as a single unit," said Jeffrey Karp, an affiliate faculty member of the Harvard-MIT Division of Health Sciences and Technology (HST) and co-corresponding author of a recent paper on the work in the Proceedings of the National Academy of Sciences.
The needle and wire proceed through the firm tissue. But once they reach the target cavity (for example, a blood vessel) there is no more resistance on the wire, and it quickly advances forward while the needle remains stationary. Because the needle is no longer moving, it cannot proceed past the cavity into the wrong tissue.
Karp believes that the device could reach clinics within three to five years pending further pre-clinical and clinical testing.
First author Erik K. Bassett, now at Massachusetts General Hospital (MGH), developed the device for his MIT master's thesis. He did so under Alexander Slocum, the Neil and Jane Pappalardo Professor of Mechanical Engineering, with guidance from Karp and Omid Farokhzad of HST, Harvard Medical School (HMS) and Brigham and Women's Hospital (Karp is also affiliated with the latter two). Additional authors are also from HMS and MGH.
Elizabeth Thomson | EurekAlert!
Skin patch dissolves 'love handles' in mice
18.09.2017 | Columbia University Medical Center
Medicine of the future: New microchip technology could be used to track 'smart pills'
13.09.2017 | California Institute of Technology
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
21.09.2017 | Physics and Astronomy
21.09.2017 | Life Sciences
21.09.2017 | Health and Medicine