Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Implantable Cuff with Electrodes

09.05.2014

Freiburg researchers develop new method for lowering high blood pressure without side effects

High blood pressure is the greatest health risk worldwide behind smoking and alcohol consumption. In Germany, around 25 percent of the population suffers from arterial hypertension, as the condition is referred to in medical circles. The microsystems engineers Dr. Dennis Plachta and Prof. Dr. Thomas Stieglitz from the Laboratory of Biomedical Microtechnology at the Department of Microsystems Engineering (IMTEK) of the University of Freiburg teamed up with the neurosurgeons Dr. Mortimer Gierthmühlen and Prof. Dr. Josef Zentner from the Medical Center – University of Freiburg to develop a new cuff equipped with electrodes that can lower blood pressure without causing side effects.


The cuff is equipped with electrodes that can lower blood pressure without causing side effects. Source: IMTEK

Doctors usually prescribe drugs against high blood pressure. In around 35 percent of patients, however, pills do not succeed in reducing blood pressure in the long term. Chronic high blood pressure leads to damage in other organs – the eyes, kidneys, the heart, and the central nervous system, in particular. In order to help patients whose blood pressure cannot be reduced by means of drugs, the Freiburg researchers propose implanting a newly developed cuff with 24 electrodes in the so-called vagal nerve on the neck. The device starts by determining which electrode is closest to the nerve fibers that transmit the blood pressure signal. Then it uses electrostimulation to overwrite the information in these fibers with such precision that other bundles of fibers with other functions are not affected. The researchers have named this procedure for individual analysis, selection, and stimulation “BaroLoopTM.”

The scientists tested the device on rats and succeeded in lowering their mean blood pressure by 30 percent, without causing side effects such as a reduced heart rate or a drastic decrease in respiratory rate. The findings of the study have been published in the Journal of Neural Engineering.

The idea for the research project originated in 2004 within the context of the establishment of the Peter Osypka Endowed Chair in Neuroelectronic Systems at the Department of Neurosurgery. Now that the scientists have determined that a cuff with electrodes is feasible in principle, they have begun to develop a completely implantable system. As such a device is classed as an active implant that must fulfill the highest level of safety standards according to medical product laws, they do not expect to produce a licensed product for at least ten years.

Original publication:
“Blood pressure control with selective vagal nerve stimulation and minimal side effects” (D T T Plachta et al. 2014 Journal of Neural Engineering 11 036011).

Melanie Hübner | Albert-Ludwigs-Universität Freiburg
Further information:
http://www.pr.uni-freiburg.de/pm/2014/pm.2014-05-09.37-en?set_language=en

Further reports about: Biomedical Engineering Implantable Laboratory Microtechnology blood drugs effects electrodes fibers pressure

More articles from Medical Engineering:

nachricht A non-invasive tool for diagnosing cancer*
21.05.2015 | The Agency for Science, Technology and Research (A*STAR)

nachricht PolyU develops novel computer intelligence system for acute stroke detection
20.05.2015 | The Hong Kong Polytechnic University

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Lasers are the key to mastering challenges in lightweight construction

Many joining and cutting processes are possible only with lasers. New technologies make it possible to manufacture metal components with hollow structures that are significantly lighter and yet just as stable as solid components. In addition, lasers can be used to combine various lightweight construction materials and steels with each other. The Fraunhofer Institute for Laser Technology ILT in Aachen is presenting a range of such solutions at the LASER World of Photonics trade fair from June 22 to 25, 2015 in Munich, Germany, (Hall A3, Stand 121).

Lightweight construction materials are popular: aluminum is used in the bodywork of cars, for example, and aircraft fuselages already consist in large part of...

Im Focus: Solid-state photonics goes extreme ultraviolet

Using ultrashort laser pulses, scientists in Max Planck Institute of Quantum Optics have demonstrated the emission of extreme ultraviolet radiation from thin dielectric films and have investigated the underlying mechanisms.

In 1961, only shortly after the invention of the first laser, scientists exposed silicon dioxide crystals (also known as quartz) to an intense ruby laser to...

Im Focus: Advance in regenerative medicine

The only professorship in Germany to date, one master's programme, one laboratory with worldwide unique equipment and the corresponding research results: The University of Würzburg is leading in the field of biofabrication.

Paul Dalton is presently the only professor of biofabrication in Germany. About a year ago, the Australian researcher relocated to the Würzburg department for...

Im Focus: Basel Physicists Develop Efficient Method of Signal Transmission from Nanocomponents

Physicists have developed an innovative method that could enable the efficient use of nanocomponents in electronic circuits. To achieve this, they have developed a layout in which a nanocomponent is connected to two electrical conductors, which uncouple the electrical signal in a highly efficient manner. The scientists at the Department of Physics and the Swiss Nanoscience Institute at the University of Basel have published their results in the scientific journal “Nature Communications” together with their colleagues from ETH Zurich.

Electronic components are becoming smaller and smaller. Components measuring just a few nanometers – the size of around ten atoms – are already being produced...

Im Focus: IoT-based Advanced Automobile Parking Navigation System

Development and implementation of an advanced automobile parking navigation platform for parking services

To fulfill the requirements of the industry, PolyU researchers developed the Advanced Automobile Parking Navigation Platform, which includes smart devices,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International symposium: trends in spatial analysis and modelling for a more sustainable land use

20.05.2015 | Event News

15th conference of the International Association of Colloid and Interface Scientists

18.05.2015 | Event News

EHFG 2015: Securing health in Europe. Balancing priorities, sharing responsibilities

12.05.2015 | Event News

 
Latest News

Quasi-sexual gene transfer drives genetic diversity of hot spring bacteria

29.05.2015 | Life Sciences

First Eastern Pacific tropical depression runs ahead of dawn

29.05.2015 | Earth Sciences

Donuts, math, and superdense teleportation of quantum information

29.05.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>