Pediatric neuroscientists at Oregon Health & Science University Doernbecher Children's Hospital are the first to use high magnetic field strength MRI to reveal tiny white matter injuries in the developing brain previously undetectable using standard MRI.
Early, accurate identification of these lesions in the preterm human infant could prevent delays in therapy and enable physicians to inform families sooner of the potential for complications. The team's findings are published in the Annals of Neurology.
White matter injury is the most common cause of chronic neurologic disability in children with cerebral palsy, explains principal investigator Stephen Back, M.D., Ph.D., but babies with cerebral palsy often have MRIs that miss injury, which creates significant challenges, including delayed treatment intervention and rehabilitation.
"Until now there hasn't been a compelling reason to put preterm babies into a high-field MRI scanner. Our work indicates the magnetic field strength of current clinical MRI may be a limiting factor to detecting some white matter lesions in the preterm infant. Now that we can detect this injury, we also hope our findings may encourage MRI researchers to find more sensitive means to detect this injury with lower field MRIs that are widely available," said Back, an associate professor of pediatrics and neurology in the Papé Family Pediatric Research Institute at OHSU Doernbecher Children's Hospital.
High-field MRI scanners are still mostly used as a research tool and not widely available outside of specialized MRI research centers like OHSU, Back added.
White matter injury occurs during brain development when nerve fibers are actively being wrapped in myelin, the insulation that allows nerve fibers to rapidly transmit signals in the brain. The cells required to make myelin can be easily destroyed when blood flow to the developing brain falls below normal or when maternal infection occurs during pregnancy. The loss of these cells disrupts brain maturation and results in failure to make the myelin required for normal brain function.
Preterm infants are particularly susceptible to these injuries, which can result in lifelong impairments, including inability to walk as well as intellectual challenges.
In this study, using high-field MRI (12-Tesla), Back and colleagues were able to identify tiny brain lesions in preterm fetal sheep with characteristics previously unseen and unreported using a standard 3-T MRI. Prior to this study, progress to developing treatments for white matter injury in the preterm infant had been hampered by clinicians' inability to see these microscopic injuries, and just one tiny lesion can have a tremendous impact on the patient's ability to walk and learn.
"Our findings support the potential of using high-field MRI for early identification, improved diagnosis and prognosis of white matter injury in the preterm infant, and our large preclinical animal model provides unique experimental access to questions directed at the cause of these lesions, as well as the optimal field strength and modality to resolve evolving lesions using MRI."
Future studies are needed to determine the clinical-translational utility of high-field MRI, Back added.
The study was funded by a Javits Award from the National Institute of Neurological Diseases and Stroke (NINDS), a branch of the National Institutes of Health; the American Heart Association; and the March of Dimes Birth Defects Foundation.
OHSU investigators who contributed to this study include: Art Riddle, Ph.D.; Justin Dean, Ph.D.; Joshua Buser; Xi Gong, M.D.; Jennifer Maire; Kevin Chen; Tahir Ahmad; Victor Cai; Thuan Nguyen, Ph.D.; Christopher D. Kroenke, Ph.D.; and A. Roger Hohimer, Ph.D.
About Stephen Back, M.D., Ph.D.
Stephen Back is an internationally recognized expert in pediatric neurology whose research looks at the mechanisms responsible for causing white matter brain injury in developing infants. His team developed the first animal model that reproduces the major forms of brain damage that occur in premature infants. This model has substantially altered the way leaders in this field believe damage occurs to the developing white matter of the brain. For more information on his work, visit the Stephen Back Lab (http://www.ohsu.edu/xd/health/services/doernbecher/research-education/research/research-labs/stephen-back-lab.cfm)
About OHSU Doernbecher Children's Hospital
(http://www.ohsudoernbecher.com) OHSU Doernbecher Children's Hospital is ranked among the top 50 children's hospitals in the United States in eight specialties.* Each year OHSU Doernbecher cares for tens of thousands of children from Oregon, southwest Washington and around the nation. Children have access to a full range of pediatric care, resulting in more than 195,000 outpatient visits, discharges, surgeries and pediatric transports annually. Nationally recognized physicians ensure that children receive exceptional care in the most patient- and family-centered environment. Pediatric experts from OHSU Doernbecher also travel throughout Oregon and southwest Washington to provide specialty care to some 3,000 children at more than 154 outreach clinics in 13 locations. OHSU Doernbecher also has a broad telemedicine program, delivering neonatal and pediatric acute care consultation to hospitals across the state. * US News Best Children's Hospitals 2011-12.
Tamara Hargens-Bradley | EurekAlert!
A Challenging European Research Project to Develop New Tiny Microscopes
28.03.2017 | Technische Universität Braunschweig
3-D visualization of the pancreas -- new tool in diabetes research
15.03.2017 | Umea University
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Life Sciences
28.03.2017 | Information Technology
28.03.2017 | Physics and Astronomy