Pediatric neuroscientists at Oregon Health & Science University Doernbecher Children's Hospital are the first to use high magnetic field strength MRI to reveal tiny white matter injuries in the developing brain previously undetectable using standard MRI.
Early, accurate identification of these lesions in the preterm human infant could prevent delays in therapy and enable physicians to inform families sooner of the potential for complications. The team's findings are published in the Annals of Neurology.
White matter injury is the most common cause of chronic neurologic disability in children with cerebral palsy, explains principal investigator Stephen Back, M.D., Ph.D., but babies with cerebral palsy often have MRIs that miss injury, which creates significant challenges, including delayed treatment intervention and rehabilitation.
"Until now there hasn't been a compelling reason to put preterm babies into a high-field MRI scanner. Our work indicates the magnetic field strength of current clinical MRI may be a limiting factor to detecting some white matter lesions in the preterm infant. Now that we can detect this injury, we also hope our findings may encourage MRI researchers to find more sensitive means to detect this injury with lower field MRIs that are widely available," said Back, an associate professor of pediatrics and neurology in the Papé Family Pediatric Research Institute at OHSU Doernbecher Children's Hospital.
High-field MRI scanners are still mostly used as a research tool and not widely available outside of specialized MRI research centers like OHSU, Back added.
White matter injury occurs during brain development when nerve fibers are actively being wrapped in myelin, the insulation that allows nerve fibers to rapidly transmit signals in the brain. The cells required to make myelin can be easily destroyed when blood flow to the developing brain falls below normal or when maternal infection occurs during pregnancy. The loss of these cells disrupts brain maturation and results in failure to make the myelin required for normal brain function.
Preterm infants are particularly susceptible to these injuries, which can result in lifelong impairments, including inability to walk as well as intellectual challenges.
In this study, using high-field MRI (12-Tesla), Back and colleagues were able to identify tiny brain lesions in preterm fetal sheep with characteristics previously unseen and unreported using a standard 3-T MRI. Prior to this study, progress to developing treatments for white matter injury in the preterm infant had been hampered by clinicians' inability to see these microscopic injuries, and just one tiny lesion can have a tremendous impact on the patient's ability to walk and learn.
"Our findings support the potential of using high-field MRI for early identification, improved diagnosis and prognosis of white matter injury in the preterm infant, and our large preclinical animal model provides unique experimental access to questions directed at the cause of these lesions, as well as the optimal field strength and modality to resolve evolving lesions using MRI."
Future studies are needed to determine the clinical-translational utility of high-field MRI, Back added.
The study was funded by a Javits Award from the National Institute of Neurological Diseases and Stroke (NINDS), a branch of the National Institutes of Health; the American Heart Association; and the March of Dimes Birth Defects Foundation.
OHSU investigators who contributed to this study include: Art Riddle, Ph.D.; Justin Dean, Ph.D.; Joshua Buser; Xi Gong, M.D.; Jennifer Maire; Kevin Chen; Tahir Ahmad; Victor Cai; Thuan Nguyen, Ph.D.; Christopher D. Kroenke, Ph.D.; and A. Roger Hohimer, Ph.D.
About Stephen Back, M.D., Ph.D.
Stephen Back is an internationally recognized expert in pediatric neurology whose research looks at the mechanisms responsible for causing white matter brain injury in developing infants. His team developed the first animal model that reproduces the major forms of brain damage that occur in premature infants. This model has substantially altered the way leaders in this field believe damage occurs to the developing white matter of the brain. For more information on his work, visit the Stephen Back Lab (http://www.ohsu.edu/xd/health/services/doernbecher/research-education/research/research-labs/stephen-back-lab.cfm)
About OHSU Doernbecher Children's Hospital
(http://www.ohsudoernbecher.com) OHSU Doernbecher Children's Hospital is ranked among the top 50 children's hospitals in the United States in eight specialties.* Each year OHSU Doernbecher cares for tens of thousands of children from Oregon, southwest Washington and around the nation. Children have access to a full range of pediatric care, resulting in more than 195,000 outpatient visits, discharges, surgeries and pediatric transports annually. Nationally recognized physicians ensure that children receive exceptional care in the most patient- and family-centered environment. Pediatric experts from OHSU Doernbecher also travel throughout Oregon and southwest Washington to provide specialty care to some 3,000 children at more than 154 outreach clinics in 13 locations. OHSU Doernbecher also has a broad telemedicine program, delivering neonatal and pediatric acute care consultation to hospitals across the state. * US News Best Children's Hospitals 2011-12.
Tamara Hargens-Bradley | EurekAlert!
Medical gamma-ray camera is now palm-sized
23.05.2017 | Waseda University
Computer accurately identifies and delineates breast cancers on digital tissue slides
11.05.2017 | Case Western Reserve University
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy