The findings, by a team led by Samir Hanash, M.D., Ph.D., head of the Hutchinson Center’s Molecular Diagnostics Program and member of its Public Health Sciences Division, are published online Sept. 12 ahead of the Sept. 13 print issue of Cancer Cell.
“A major feature of this study was that we were able to replicate findings from mouse models of lung cancer in blood samples from humans with lung cancer both at the time of diagnosis and, importantly, prior to the onset of symptoms and diagnosis,” Hanash said. “Our data showed that the protein markers that were tested showed similar concordance between lung cancer in the mouse and lung cancer in humans. This means that developing a blood test to detect lung cancer is increasingly within reach.”
The blood protein signatures discovered in the future may be used in a blood test to not only screen for lung cancer among high-risk individuals such as current and former smokers, but to aid in diagnosis, distinguishing between various subtypes of the disease, such as small-cell lung cancer and lung adenocarcinoma.
Hanash envisions that such a test could be used together with imaging technologies such as CT screening to monitor people at high risk of developing the disease.
“There is a substantial need for simple, non-invasive means to detect lung cancer. While imaging-based screening to detect lung cancer has shown promise, blood-based diagnostics provide a complementary means for detection, disease classification, and monitoring for cancer progression and regression,” the authors wrote.For the study, the researchers conducted in-depth blood protein analysis of three mouse models of lung adenocarcinoma and a genetically engineered mouse model of small-cell lung cancer. To further refine the results, they compared these lung cancer protein profiles to those from other well-established mouse models of pancreatic, ovarian, colon, prostate and breast cancer, as well as two mouse models of inflammation without the presence of cancer. Several protein signatures emerged that were specific to lung cancer:
• In a model of small-cell lung cancer, the researchers found a distinct blood protein signature that was associated with neuroendocrine development.
To determine whether these protein signatures in mice were relevant to human lung cancer, the researchers analyzed blood samples from 28 smokers who had been newly diagnosed with operable lung cancer and blood samples from 26 other subjects that were obtained up to a year before lung cancer was diagnosed. For comparison purposes they also analyzed blood from a similar number of matched, cancer-free controls.
The researchers found striking similarities between the protein signatures in mice and human. For example, in mice with small-cell lung cancer, they found elevated levels of a neural protein called Robo1. They also found significantly increased levels of this protein in patients with small-cell lung cancer as compared to matched human controls.
“Additional validation studies are in progress to further determine the sensitivity and specificity of the marker panels,” Hanash said.
Collaborators on the study included researchers from Memorial Sloan-Kettering Cancer Center, the National Human Genome Research Institute, Yale University School of Medicine, Stanford University, the University of Texas Southwestern Medical Center, and Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School.
Funding for the research came from the NCI Mouse Models of Human Cancer Program, the NCI Early Detection Research Network, the Canary Foundation, the Thomas G. Labrecque Foundation, the Uniting Against Lung Cancer Foundation, the Department of Defense Congressionally Directed Lung Cancer Research Program and the Parker B. Francis Fellowship Program of the Francis Family Foundation.
Note for media only: To obtain a copy of the embargoed Cancer Cell paper, “Lung Cancer Signatures in Plasma Based on Proteome Profiling of Mouse Tumor Models,” please contact Mary Beth O’Leary in the journal’s press office at firstname.lastname@example.org or 617-397-2802. To arrange an interview with Hanash, please contact Kristen Woodward in media relations at the Hutchinson Center at email@example.com or 206-667-5095.
At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit fhcrc.org.
Kristen Woodward | Newswise Science News
Biologists unravel another mystery of what makes DNA go 'loopy'
16.03.2018 | Emory Health Sciences
Scientists map the portal to the cell's nucleus
16.03.2018 | Rockefeller University
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
16.03.2018 | Earth Sciences
16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences