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PhysioStim offers cardiac pharmacological model for compound assays

23.11.2007
PhysioStim of France, a specialist in cardiac safety pharmacology, is setting up a new model for isolated cardiomyocytes, which will record all types of ionic currents and action potentials. This model will provide an overview of cardiac physiological mechanisms, drawn up at cellular level.

Testing to detect any possible risk of cardiac toxicity induced by pharmaceuticals is crucial during the preclinical R&D stage. PhysioStim has solid and reliable expertise in this highly specialised area, particularly with hERG assays – potassium channels that are essential in cardiac repolarisation problems.

However, in order to obtain a much more comprehensive and integrative approach to cardiac problems, PhysioStim’s experts also offer cardiac action potential recordings, which mimic in vitro the electrophysiological properties that are observable in vivo.

The isolated cells obtained show the proteinic structures and the physiological and biochemical properties preserved, with the advantage of providing a population of cells without neuronal or hormonal influence in a totally controllable environment.

Philip Jolly | alfa
Further information:
http://www.ftpb.co.uk

Further reports about: Model PhysioStim assays cardiac

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