In concrete, the Biotechnology Laboratory team at the University Hospital (University of Navarra), in close collaboration with the Pharmacogenomics laboratory at the Centre for Applied Medical Research (CIMA) of the same University, undertook these analyses predictive of responses to pharmaceutical drugs in patients with cancer of the lung, the colon and certain types of sarcoma.
Research into the mutations of a gene known as EGFR that can be found altered in lung cancer may help to determine the response of a new group of pharmaceutical – the tyrosine quinase inhibitors of the epidermic growth factor receptor. Also, the presence of genetic changes in specific fragments of PDGFR-alfa genes as well a sin the c-kit gene can pinpoint which treatment is likely to be more efficacious in certain gastrointestinal sarcomas. In this respect, the Department of Oncology at the University Hospital (University of Navarra) and the Centre for Applied Medical Research (CIMA) of the same University are collaborating in the identification of these genetic changes based on the study of the tumour prior to the application of treatment in the patient.
We are currently analysing genetic changes which will help us define the parameters needed to interpret what the best set of pharmaceutical drugs might be to act on certain tumours, particularly cancers of the lung, of the colon and sarcomas.
DIn this way, which patients best respond to a specific treatment can be identified. At the same time, we manage to know the toxicity profile that may occur using these medicinal drugs.
The procedure consists of a genetic analysis of a blood sample or of the cancerous tissue where the existence of certain mutations or polymorphisms are observed and enable us to predict what drugs are the most suitable for that particular patient. The analysis provides us with information about the most effective therapeutic option against the tumour, as well as what the potential side-effects are of this treatment on the patient. In this way a better therapeutic selection and individualisation for each patient is achieved.
The analysis of certain genetic variants called polymorphisms help to predict an increased toxicity risk due to treatment with certain antineoplasic pharmaceuticals. Providing the most suitable drug to each patient will mean reducing the symptoms of the toxicity - fatigue, digestive indisposition, cutaneous reaction, diarrhoea, vomiting, as well as alterations in the liver and kidney. In this way the patient will have a better quality of life.
A number of research projects undertaken by different teams have confirmed the use of these markers for response and toxicity and their role in drawing up more individualised therapeutic plan.
Irati Kortabitarte | alfa
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research