In concrete, the Biotechnology Laboratory team at the University Hospital (University of Navarra), in close collaboration with the Pharmacogenomics laboratory at the Centre for Applied Medical Research (CIMA) of the same University, undertook these analyses predictive of responses to pharmaceutical drugs in patients with cancer of the lung, the colon and certain types of sarcoma.
Research into the mutations of a gene known as EGFR that can be found altered in lung cancer may help to determine the response of a new group of pharmaceutical – the tyrosine quinase inhibitors of the epidermic growth factor receptor. Also, the presence of genetic changes in specific fragments of PDGFR-alfa genes as well a sin the c-kit gene can pinpoint which treatment is likely to be more efficacious in certain gastrointestinal sarcomas. In this respect, the Department of Oncology at the University Hospital (University of Navarra) and the Centre for Applied Medical Research (CIMA) of the same University are collaborating in the identification of these genetic changes based on the study of the tumour prior to the application of treatment in the patient.
We are currently analysing genetic changes which will help us define the parameters needed to interpret what the best set of pharmaceutical drugs might be to act on certain tumours, particularly cancers of the lung, of the colon and sarcomas.
DIn this way, which patients best respond to a specific treatment can be identified. At the same time, we manage to know the toxicity profile that may occur using these medicinal drugs.
The procedure consists of a genetic analysis of a blood sample or of the cancerous tissue where the existence of certain mutations or polymorphisms are observed and enable us to predict what drugs are the most suitable for that particular patient. The analysis provides us with information about the most effective therapeutic option against the tumour, as well as what the potential side-effects are of this treatment on the patient. In this way a better therapeutic selection and individualisation for each patient is achieved.
The analysis of certain genetic variants called polymorphisms help to predict an increased toxicity risk due to treatment with certain antineoplasic pharmaceuticals. Providing the most suitable drug to each patient will mean reducing the symptoms of the toxicity - fatigue, digestive indisposition, cutaneous reaction, diarrhoea, vomiting, as well as alterations in the liver and kidney. In this way the patient will have a better quality of life.
A number of research projects undertaken by different teams have confirmed the use of these markers for response and toxicity and their role in drawing up more individualised therapeutic plan.
Irati Kortabitarte | alfa
Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
26.04.2017 | Materials Sciences
26.04.2017 | Agricultural and Forestry Science
26.04.2017 | Physics and Astronomy