Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sox17 required for steps from embryonic to heart muscle cell

27.02.2007
An important choreographer of the complicated dance of signals, enzymes and proteins that takes embryonic stem cells through the steps to becoming a beating heart muscle cell is the gene Sox17, said researchers from Baylor College of Medicine in a report in the current issue of the Proceedings of the National Academy of Sciences.

To be precise, Sox17 is critical in transforming primitive mesoderm (an early layer of tissue in the embryo) into the more specialized cardiac mesoderm from which heart muscle develops, said Dr. Michael Schneider, senior researcher of the report.

"Heart muscle formation by embryonic stem cells is a complex, multi-step process," said Schneider, professor of medicine, molecular and cellular biology, and molecular physiology and biophysics at Baylor College of Medicine. "We have succeeded in uncoupling the formation of cardiac mesoderm from its antecedent steps. That discovery provides immediate insight into how one might seek to generate cardiac muscle more effectively from embryonic stem cells."

"One of the major challenges is the very meager ability of the heart muscle to restore itself after cell death," said Schneider. Heart muscle cells die acutely during heart attacks and sporadically in chronic heart failure.

"Identifying stem cells that can be encouraged along the path to becoming heart muscle is a paramount scientific goal," he said.

Embryonic stem cells are a potential source because they have the potential of becoming every type of cell in the body. However, much research remains before scientists can outline a blueprint for how these totally undifferentiated cells can be guided to the "fate" of becoming heart muscle selectively.

Schneider and his colleagues used proteins that block certain signals for cell specialization at the surface of mouse embryonic stem cells to pinpoint early steps that lead to the development of heart muscle. Then, using "gene chip" technology to measure the expression of 40,000 mouse genes simultaneously, Schneider and his colleagues identified the sudden expression of Sox17 as a potentially important step for the signals that lead to heart formation.

Using a technique called RNA interference, they then blocked the action of Sox17 in the embryonic stem cells. By doing so, they prevented the embryonic cells from becoming cardiac muscle, almost completely.

"Knocking down Sox17 (reducing expression of the gene) had a dramatic effect, both on genes for structural components of the heart and also genes for transcription factors that turn on the cardiac fate," said Schneider.

Ross Tomlin | EurekAlert!
Further information:
http://www.bcm.edu

Further reports about: Embryonic Sox17 cardiac embryonic stem cell heart muscle

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>