Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research to spotlight carbon monoxide benefits

23.01.2007
Scientists at the University of York have won a grant of £110,000 to investigate potential uses of carbon monoxide in treating disease.

Dr Jason Lynam and Dr Ian Fairlamb, of the University’s Department of Chemistry, have been awarded the funding by the Leverhulme Trust for a three-year study into the use of metal compounds for the controlled release of carbon monoxide into the bloodstream.

Carbon monoxide is an anti-inflammatory, and they want to explore its potential in treating high blood pressure, heart disease and possibly cancer. The project builds on a study conducted by Roberto Motterlini (Northwick Park Hospital in London) and Professor Brian Mann (University of Sheffield), and preliminary studies conducted in York, supported by funds from the University and Engineering and Physical Sciences Research Council (EPSRC).

Dr Fairlamb said: “You can use certain carbon monoxide molecules to elicit a whole range of biological effects. Carbon monoxide causes vasorelaxation and is produced naturally as a result of the breakdown of haemoglobin. This can be seen in the healing process of a bruise, where various colour changes indicate the degradation of haemoglobin and release of carbon monoxide. The slow release of carbon monoxide reduces blood pressure for someone who has angina, for instance.

... more about:
»Carbon »carbon monoxide »monoxide

“This work is very much in its infancy. We became involved because some of our organometallic compounds, which carry carbon monoxide, were showing potential to release carbon monoxide slowly in a controlled manner. They degrade to give benign non-toxic products which do not target immune response.”

Dr Lynam added: “We don’t want to administer carbon monoxide in its normal toxic gaseous form; rather we want to develop molecules that will release it in a sort of slow trickle feed. We aim to make tuneable compounds which allow you to alter the rate at which carbon monoxide is released, which could be important in different bioapplications.

“We are adopting a complementary approach to the design of these molecules using the natural interface between organic and inorganic chemistry.”

The project will examine the physical and electronic characteristics of potentially suitable compounds and identify those which are absorbed best by the body with the aim of starting clinical studies in three years’ time.

David Garner | alfa
Further information:
http://www.york.ac.uk/depts/chem/
http://www.york.ac.uk/admin/presspr/pressreleases/carbonmonoxideresearch.htm
http://www.leverhulme.ac.uk

Further reports about: Carbon carbon monoxide monoxide

More articles from Life Sciences:

nachricht Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington

nachricht The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Gold shines through properties of nano biosensors

17.08.2017 | Physics and Astronomy

Greenland ice flow likely to speed up: New data assert glaciers move over sediment, which gets more slippery as it gets wetter

17.08.2017 | Earth Sciences

Mars 2020 mission to use smart methods to seek signs of past life

17.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>