Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

First familial pancreatic cancer gene identified

12.12.2006
Pancreatic cancer is relatively rare but deadly; most patients die within a year of diagnosis, and it is the fourth leading cause of cancer deaths in the US. At least 10% of pancreatic cancers are thought to be familial, i.e., caused by inherited genetic mutations.

The responsible genes have so far remained elusive, but one of the research teams that had been on a pancreatic cancer gene hunt for years now reports success: Teri Brentnall (University of Washington), David Whitcomb (University of Pittsburgh), and colleagues publish the identification of the palladin gene as the one mutated in a large family they had been studying for a while.

Family X, as it is referred to, has 18 members from 4 generations who had either pancreatic cancer or precancerous lesions of the pancreas. Tracing the DNA segments that are shared by these patients but not present in the healthy family members, the researchers had previously mapped the gene to a relatively small region of chromosome 4, which contains 243 known genes. They then made a gene chip that can measure expression levels of these 243 candidate genes and compared normal pancreas tissue with cancerous pancreas (both from a Family X member and from unrelated patients with pancreatic cancer).

Palladin, one of the 243 genes, turned out to be abnormally highly expressed in both the Family X tissue and the sporadic cancers. Named after the 16th century Italian architect Palladio, palladin codes for a component of the cytoskeleton (the scaffold that helps to control cell shape and motility). Next, the researchers quantified the expression of palladin RNA in an independent set of normal and cancerous pancreatic samples, and in precancerous pancreatic tissue taken from family X members. This analysis indicated that palladin was overexpressed early in sporadic and inherited pancreatic cancer development. Sequencing of the palladin gene then uncovered a mutation in palladin that was present in Family X members with pancreatic cancer or precancerous lesions but not in unaffected members. Finally, the researchers showed that the introduction of mutated palladin into a human cell line growing in the laboratory increased its migration rate and disrupted its cytoskeleton (both features typical of cancer cells).

... more about:
»palladin »pancreatic cancer

These results leave little doubt that mutated palladin is involved in the development of pancreatic cancer in Family X. Moreover, they suggest that overexpression of palladin is also associated with and possibly responsible for a sizeable proportion of sporadic pancreatic cancers. The identification of palladin as a “pancreatic cancer gene” provides researchers with a molecular entry point into the cellular processes underlying this cancer and will hopefully help to improve diagnosis and development of new treatments for this deadly disease.

Andrew Hyde | alfa
Further information:
http://www.plosmedicine.org/

Further reports about: palladin pancreatic cancer

More articles from Life Sciences:

nachricht The big clean up after stress
25.05.2018 | Julius-Maximilians-Universität Würzburg

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>