The sequencing of human chromosome 3 announced in the current issue of the journal Nature represents a milestone for the Baylor College of Medicine Human Genome Sequencing Center – the final stage of its multi-year project to sequence the human genome.
Researchers at the BCM genome sequencing center in Houston are now using the information to discover the genetic basis for human disease, said Dr. Richard Gibbs, director of the BCM center and Dr. George Weinstock, co-director.
Sequencing chromosome 3 was also an international collaboration among teams from the United States (including Baylor College of Medicine in Houston), Germany and The People’s Republic of China.
The lead author of the paper was BCM scientist Donna Muzny, but she and Dr. Steven Scherer, associate professor in the BCM Human Genome Sequencing Center, credit Dr. Huanming Yang and the Chinese sequencing group with playing a critical role in the effort. His group determined the DNA sequence of a portion of the chromosome and characterized important elements that regulate how the DNA is translated into proteins critical to the functioning of the cell.
Yang, of the Beijing Genomes Institute of the Chinese Academy of Sciences and his colleagues also played host to an international sequencing consortium strategy meeting in 2001.
"Human genome sequencing presented a unique opportunity for China to join the international community. I salute all our friends and colleagues at the collaborating institutions for their contributions to this task and for their support of free data-sharing under the spirit of the Human Genome Project that is ’owned by all, done by all and shared by all," said Yang
"This work represents many years of collaborative effort and defines human chromosome 3 using state-of-the-art sequence quality and extraordinarily detailed manual annotation," said Gibbs.
The BCM Sequencing Center produced the sequences of chromosomes 3, 12 and X – about 10 percent of the human gene. (The sequences of the other two chromosomes appeared in earlier reports in Nature.)
"Over the more than a decade that this work continued, more than 700 researchers working an equal number at collaborating institutions painstakingly determined the exact order of genetic letter sin the human genetic doe and how they spell out the genes of mankind," said Weinstock.
Sequencing chromosome 3, which contained 199 million bases (or chemicals that are the building blocks of DNA), also involved scientists from The University of Texas Health Science Center at San Antonio, the University of Washington Genome Center and the Max Planck Institute in Berlin.
Ross Tomlin | EurekAlert!
Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Power and Electrical Engineering
16.01.2017 | Information Technology
16.01.2017 | Power and Electrical Engineering