The sequencing of human chromosome 3 announced in the current issue of the journal Nature represents a milestone for the Baylor College of Medicine Human Genome Sequencing Center – the final stage of its multi-year project to sequence the human genome.
Researchers at the BCM genome sequencing center in Houston are now using the information to discover the genetic basis for human disease, said Dr. Richard Gibbs, director of the BCM center and Dr. George Weinstock, co-director.
Sequencing chromosome 3 was also an international collaboration among teams from the United States (including Baylor College of Medicine in Houston), Germany and The People’s Republic of China.
The lead author of the paper was BCM scientist Donna Muzny, but she and Dr. Steven Scherer, associate professor in the BCM Human Genome Sequencing Center, credit Dr. Huanming Yang and the Chinese sequencing group with playing a critical role in the effort. His group determined the DNA sequence of a portion of the chromosome and characterized important elements that regulate how the DNA is translated into proteins critical to the functioning of the cell.
Yang, of the Beijing Genomes Institute of the Chinese Academy of Sciences and his colleagues also played host to an international sequencing consortium strategy meeting in 2001.
"Human genome sequencing presented a unique opportunity for China to join the international community. I salute all our friends and colleagues at the collaborating institutions for their contributions to this task and for their support of free data-sharing under the spirit of the Human Genome Project that is ’owned by all, done by all and shared by all," said Yang
"This work represents many years of collaborative effort and defines human chromosome 3 using state-of-the-art sequence quality and extraordinarily detailed manual annotation," said Gibbs.
The BCM Sequencing Center produced the sequences of chromosomes 3, 12 and X – about 10 percent of the human gene. (The sequences of the other two chromosomes appeared in earlier reports in Nature.)
"Over the more than a decade that this work continued, more than 700 researchers working an equal number at collaborating institutions painstakingly determined the exact order of genetic letter sin the human genetic doe and how they spell out the genes of mankind," said Weinstock.
Sequencing chromosome 3, which contained 199 million bases (or chemicals that are the building blocks of DNA), also involved scientists from The University of Texas Health Science Center at San Antonio, the University of Washington Genome Center and the Max Planck Institute in Berlin.
Ross Tomlin | EurekAlert!
A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to developing a new active ingredient against chronic infections
21.08.2017 | Deutsches Zentrum für Infektionsforschung
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
21.08.2017 | Medical Engineering
21.08.2017 | Materials Sciences
21.08.2017 | Life Sciences