Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Puffer fish raw and rich

26.10.2001


Draft Fugu genome will help find human genes.


The puffer will help pinpoint human genes.
© Underwaterphotography.com



A draft sequence of the puffer-fish genome is complete. The fish’s compact genetics should accelerate the discovery of human genes and their key controlling sequences.

Gene-prediction programs struggle to find genes in the 3 billion letters of the human sequence, which includes swathes of junk DNA and defunct pseudogenes.


The bony fish Fugu rubripes shares our gene repertoire but has a genome one-eighth of the size. Its sequence "is easier to sift through for genes", says Greg Elgar of the UK Human Genome Mapping Project Resource Centre in Hinxton, a partner in the international sequencing effort.

The rough sequence covers 99% of Fugu’s DNA. It should help to settle the much-disputed estimate of gene number in humans. Current figures for Fugu are around 35,000-40,000; most recent human approximations are 30,000-40,000.

Crucial sequences that control how actively genes make proteins are also very similar in puffer fish and humans, explains Elgar, despite the fact that their most recent common ancestor lived 45 million years ago.

"[These sequences] are the most exciting targets for therapeutics," says Elgar. Members of the consortium are now undertaking large-scale genome analyses to pinpoint these regulatory regions.

The Fugu genome project used ’whole-genome shotgun’ sequencing, a technique pioneered by the commercial human-genome sequencers Celera, in which fragments are read and then pieced together.

The draft announcement comes only a year after the consortium, based in the United States, Singapore and the United Kingdom, embarked on the project. They plan to publish an analysis in early 2002 and are making all sequence information freely available.




HELEN PEARSON | Nature News Service
Further information:
http://www.nature.com/nsu/011101/011101-3.html
http://www.nature.com/nsu/

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>