By comparing 140 sequenced bacterial genomes, researchers have uncovered a system for regulating genes essential to bacterial replication - and they did it solely by computer keystrokes and mouse clicks.
Mikhail Gelfand, a Howard Hughes Medical Institute international research scholar at the Institute for Information Transmission Problems (IITP) in Moscow, and his postdoctoral fellow, Dmitry Rodionov, used comparative genomics to identify a new transcription factor system in bacteria that represses expression of genes involved in DNA replication. They scanned gene sequences and proteomes of several taxonomic groups of bacteria, identifying not only a highly conserved signal sequence, but also the regulatory transcription factor that bound it, the repressor nature of the signal, and other genes also regulated by this system.
“We provided a very detailed description of a system just by doing bioinformatics alone,” says Gelfand, director of the IITPs research and training center of bioinformatics. “Its a proof of principle that you can go a very long way by comparative genomics now.” Their findings will be published in the July issue of Trends in Genetics, with early publication now online. Gelfand is presenting the work on June 24, 2005, at the annual meeting of HHMI international research scholars in Mérida, Mexico.
Cindy Fox Aisen | EurekAlert!
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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