Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers show new drug may help treat certain forms of leukemia

03.05.2005


A new experimental drug may be effective against a certain form of leukemia resistant to current treatments, research at UT Southwestern Medical Center shows.



"This novel anti-leukemia drug that we have been working on shows considerable promise for going into the clinic," said Dr. Robert Ilaria Jr., associate professor of internal medicine and molecular biology and senior author of the study that will appear in an upcoming issue of Blood. The study is available online.

The study on the drug, called PD166326, was done in mice with a form of leukemia similar to human chronic myelogenous leukemia (CML), which is diagnosed in about 5,000 people in the United States each year. Patients with CML produce a mutated enzyme that stimulates white blood cells to overproduce, causing leukemia.


The Blood study shows that PD166326 is nearly 100 times more potent than the current drug imatinib (Gleevec) against cells expressing this enzyme, Dr. Ilaria said.

"Our study represents the first published characterization of this novel anti-leukemia drug in animals," Dr. Ilaria said. Gleevec is approved by the Food and Drug Administration for the treatment of patients with CML. The drug blocks signals within cancer cells and prevents a series of chemical reactions that cause the cells to grow and divide.

Although Gleevec has been highly successful against CML, it is unknown whether the drug can permanently eradicate all leukemia cells with the specific aberrant enzyme found in CML patients. About 15 percent to 20 percent of patients who take Gleevec become resistant to the drug and relapse, leaving few effective treatment options.

In the Blood study, Dr. Ilaria and his colleagues introduced the cancer-causing enzyme into mouse bone-marrow cells to generate mice with a form of leukemia similar to human CML. The disease usually develops slowly, although it can progress to an accelerated phase.

When mice received a single oral dose of PD166326, the mutated enzyme activity was rapidly inhibited, and the white blood count significantly decreased. Two-thirds of the PD166326-treated mice also had complete recovery from splenomegaly, an abnormal enlargement of the spleen, compared to none treated with Gleevec, Dr. Ilaria said.

In long-term use, PD166326 showed better anti-leukemia activity than Gleevec, and it also prolonged the survival of mice with the CML-like leukemia resistant to Gleevec treatment.

While PD166326 is not yet available for clinical trials, investigators at Memorial Sloan-Kettering Cancer Center in New York, who synthesized the drug, are working with a major pharmaceutical company that owns the patent for this class of drugs on its clinical development, Dr. Ilaria said. Its relatively long half-life in mice indicates once-daily dosing might be possible in humans.

PD166326 is in a different class of anti-leukemia drugs currently being investigated by other researchers for their effectiveness in Gleevec-resistant patients. Dr. Ilaria’s lab is continuing research in Gleevec resistance and looking at combining this new compound with other drugs.

"CML patients may soon have multiple choices with Gleevec and any one or all of the additional classes of drugs in development," Dr. Ilaria said. "These compounds also may work on other solid tumors, so it will be very interesting to see how it all pans out."

Nicholas C. Wolff, research associate in the Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, is first author of the Blood study.

Scott Maier | EurekAlert!
Further information:
http://www.utsouthwestern.edu

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>