Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Signaling pathway may be key to understanding roots of hypertension

12.11.2004


Defeating high blood pressure may be a matter of a little molecular manipulation.



Some drugs for hypertension, such as so-called ACE inhibitors, block specific receptor proteins on the cell. But researchers at Jefferson Medical College instead have looked to a certain molecular pathway called the Gq signaling pathway, showing that it plays an important role in developing various models of hypertension. The work might lead to new insights into the roots of hypertension, and eventually, the scientists believe, novel therapies.

Andrea Eckhart, Ph.D., associate professor of medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia and her co-workers focused on drugs known as alpha-adrenergic receptor blockers and angiotensin II receptor blockers (including ACE inhibitors), which block angiotensin over-production, and which can lead to high blood pressure. Both of these receptors normally bind to a class of receptors called Gq, which ultimately leads to hypertension.


"We thought that if we could somehow block all of the receptors bound to this Gq coupled protein, then instead of hitting each receptor individually, we could knock them all out with a specific inhibitor," explains Dr. Eckhart, who presented her team’s results this week at the American Heart Association’s Scientific Sessions 2004 in New Orleans.

Dr. Eckhart, who is director of the Eugene Feiner Laboratory in the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College, and her team subsequently developed a Gq inhibitor and tested it in various mouse models of hypertension. They looked at two particular receptor proteins called GRK2 and GRK5, which are both linked to high blood pressure in human and animal models. They overexpressed the genes for GRK2 and GRK5, causing hypertension in mice.

When they mated the GRK2 mouse with a mouse with a genetic inhibition of Gq, the resulting offspring had lower blood pressure. But when the researchers mated the GRK5 mouse with a mouse with a Gq inhibition, the offspring’s blood pressure didn’t change.

"This finding suggests that the overexpression of both proteins leads to different pathways causing high blood pressure," she says. According to Dr. Eckhart, finding the right kind of drug for patients is difficult without knowing the underlying causes of the high blood pressure. Because potential contributing factors can include obesity, genetics, and other lifestyle factors such as smoking and diet, patients often are taking several drugs at once.

"The Gq pathway is a good molecular tool that allows us to start looking in the laboratory at discerning different pathways underlying high blood pressure," she says. "It also might provide insights on developing potential therapeutic strategies especially relevant for individuals taking more than one drug at a time."

Steve Benowitz | EurekAlert!
Further information:
http://www.jefferson.edu

More articles from Life Sciences:

nachricht New technology offers fast peptide synthesis
28.02.2017 | Massachusetts Institute of Technology

nachricht Biofuel produced by microalgae
28.02.2017 | Tokyo Institute of Technology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New technology offers fast peptide synthesis

28.02.2017 | Life Sciences

WSU research advances energy savings for oil, gas industries

28.02.2017 | Power and Electrical Engineering

Who can find the fish that makes the best sound?

28.02.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>