Defeating high blood pressure may be a matter of a little molecular manipulation.
Some drugs for hypertension, such as so-called ACE inhibitors, block specific receptor proteins on the cell. But researchers at Jefferson Medical College instead have looked to a certain molecular pathway called the Gq signaling pathway, showing that it plays an important role in developing various models of hypertension. The work might lead to new insights into the roots of hypertension, and eventually, the scientists believe, novel therapies.
Andrea Eckhart, Ph.D., associate professor of medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia and her co-workers focused on drugs known as alpha-adrenergic receptor blockers and angiotensin II receptor blockers (including ACE inhibitors), which block angiotensin over-production, and which can lead to high blood pressure. Both of these receptors normally bind to a class of receptors called Gq, which ultimately leads to hypertension.
Steve Benowitz | EurekAlert!
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