In order to divide, cells must first replicate their chromosomes. Cells use an array of proteins to accomplish the job, including a large enzyme complex that synthesizes new strands of DNA. In a paper to be published Oct. 22 in the journal Molecular Cell, University of Minnesota researchers report that a particular protein, called minichromosome maintenance protein 10 (Mcm10), protects the enzyme from destruction and, like a molecular tugboat, escorts it to its "port"--the location on a chromosome where DNA replication will begin. Mcm10s versatility implies that it is indispensable for cell division. Therefore, drugs that target Mcm10 could be effective in stopping the uncontrolled cell division seen in cancerous tumors.
The work grew out of a desire to learn the identity of the "tugboat," said Anja Bielinsky, an assistant professor of biochemistry, molecular biology and biophysics, in whose laboratory the work was performed. The first author on the paper is Robin Ricke, a graduate student. The two scientists worked with bakers yeast, an organism often used to study basic biological mechanisms.
First, a little background on how DNA replicates itself: Before DNA replication can begin, the two strands in the DNA double helix must be unwound. Next, multiple molecules of a certain protein attach to the strands to keep them from spontaneously sticking together again. Only then can the star of the show--DNA polymerase alpha, the enzyme complex that synthesizes new DNA strands--be escorted to the specific sites on the DNA strands where it can attach and go to work.
Deane Morrison | EurekAlert!
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26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy