Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Evidence builds for potential new cancer drug target

28.09.2004


In a paper published today in the Proceedings of the National Academy of Sciences, Temple University researchers report that one of the functions of the c-myb gene, which leukemia cells depend on for proliferation, is the formation of white blood cells.



"This study is another step in the process of validating the c-myb gene as a potential target for new cancer drugs," said Prem Reddy, Ph.D., professor and director of the Fels Institute for Cancer Research and Molecular Biology at Temple University School of Medicine.

Knowing that the c-myb gene played a role in the spread of leukemia, the researchers wanted to determine the gene’s normal function. This was accomplished by deleting the c-myb gene in a mouse model. New technology allowed the scientists to delete c-myb from one specific type of tissue in the model rather than from the entire organism. "We removed the c-myb gene from T cells and in the process discovered that c-myb is required for white blood cell formation," said Reddy. In other research conducted by the team but not yet published, c-myb was deleted from breast tissue. The researchers believe that this gene plays a critical role in breast cancer and want to show the effects of its deletion on breast tumor cell proliferation.


The group’s research is providing detailed genetic explanations of how and why c-myb is essential for the proliferation of white blood cells and breast cells by demonstrating that when it’s removed, cell proliferation is impaired and the risk of developing cancer is reduced. "We hope to develop a drug that blocks the harmful activity of this gene in the near future. This finding was very serendipitous. We used to think c-myb was only associated with the development of leukemia but found that it’s also involved in the development of breast cancer," said Reddy.

Other researchers on the team include the study’s first author, Yen K. Lieu, Atul Kumar, Anthony G. Pajerowski, and Thomas J. Rogers.

Eryn Jelesiewicz | EurekAlert!
Further information:
http://www.temple.edu

More articles from Life Sciences:

nachricht The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences

nachricht Transforming plant cells from generalists to specialists
07.12.2016 | Duke University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>