In a paper published today in the Proceedings of the National Academy of Sciences, Temple University researchers report that one of the functions of the c-myb gene, which leukemia cells depend on for proliferation, is the formation of white blood cells.
"This study is another step in the process of validating the c-myb gene as a potential target for new cancer drugs," said Prem Reddy, Ph.D., professor and director of the Fels Institute for Cancer Research and Molecular Biology at Temple University School of Medicine.
Knowing that the c-myb gene played a role in the spread of leukemia, the researchers wanted to determine the genes normal function. This was accomplished by deleting the c-myb gene in a mouse model. New technology allowed the scientists to delete c-myb from one specific type of tissue in the model rather than from the entire organism. "We removed the c-myb gene from T cells and in the process discovered that c-myb is required for white blood cell formation," said Reddy. In other research conducted by the team but not yet published, c-myb was deleted from breast tissue. The researchers believe that this gene plays a critical role in breast cancer and want to show the effects of its deletion on breast tumor cell proliferation.
Eryn Jelesiewicz | EurekAlert!
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30.03.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
Transport of molecular motors into cilia
28.03.2017 | Aarhus University
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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