Emory University scientists have for the first time used a new class of luminescent "quantum dot" nanoparticles in living animals to simultaneously target and image cancerous tumors. The quantum dots were encapsulated in a highly protective polymer coating and attached to a monoclonal antibody that guided them to prostate tumor sites in living mice, where they were visible using a simple mercury lamp. The scientists believe the ability to both target and image cells in vivo represents a significant step in the quest to eventually use nanotechnology to target, image, and treat cancer, cardiovascular plaques, and neurodegenerative disease in humans. The findings were published on-line July 18 in the journal Nature Biotechnology and will appear in the journals August 1 print edition.
The research team was led by Shuming Nie, PhD, a nanotechnology expert and a professor in the Coulter Department of Biomedical Engineering at Emory and the Georgia Institute of Technology and in Emorys Winship Cancer Institute, and by Lelund Chung, PhD, professor of urology in Emory University School of Medicine and the Winship Cancer Institute. Quantum dots are nanometer-sized luminescent semiconductor crystals that have unique chemical and physical properties due to their size and their highly compact structure. Quantum dots can be chemically linked (conjugated) to molecules such as antibodies, peptides, proteins or DNA and engineered to detect other molecules, such as those present on the surface of cancer cells.
The researchers injected human prostate cancer cells under the skin of mice to promote growth of solid prostate tumors. They then encapsulated quantum dots, made from cadmium selenide, within a highly protective coating called an ABC triblock copolymer, and over-coated the particle-polymer composite with poly (ethylene glycol). They injected the quantum dots into the circulatory system of the mice first to test "passive" targeting of the tumor. Tumors grow extra blood vessels in a process called angiogenesis. These angiogenic vessels are very porous, which allowed the quantum dots to leak out and accumulate at the tumor sites, where they could be detected by fluorescence imaging.
Holly Korschun | EurekAlert!
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research