Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Norwich scientists part of EU project to fight drug-resistant ’superbugs’

12.07.2004


The John Innes Centre (JIC)Norwich, has today announced its key role in an EU-funded consortium to develop novel antibiotics in the war against drug-resistant superbugs. The ’CombiGyrase’ consortium of 7 laboratories from Germany, Italy, Spain, Switzerland and the UK will receive 1.56 million Euros over three years, with 228,000 Euros (£150,000) going to the JIC.



"There is a lot of concern about the rise of drug-resistant bacteria, so called superbugs, such as MRSA", says Professor Tony Maxwell (Head of the Biological Chemistry Department at JIC and leader of the Norwich team) "at a time when big pharmaceutical companies have reduced antibiotic research. There is a pressing need for small companies, supported by high-quality academic research, to fill this gap. This European consortium can take advantage of the expertise that exists across Europe to research and develop new drugs that are urgently needed".

The project will use novel combinatorial methods to develop new antibacterial agents that target the enzyme DNA gyrase. Gyrase is a bacterial enzyme that has already been exploited as a target for other very successful antibiotics. Combinatorial biosynthesis is a novel technology that uses genetic manipulation to improve the chemical properties and pharmacological activity of naturally occurring compounds.


The Norwich team, which includes 5 scientists from the JIC, has a key role in the consortium, testing new compounds and working out how they interact with the target, DNA gyrase.

“This consortium is an ideal platform to expand the diversity of potent gyrase inhibitors found in nature by methods of combinatorial biosynthesis“, says Professor Lutz Heide, the co-ordinator of the CombiGyrase project.

Ray Mathias | alfa
Further information:
http://www.jic.ac.uk

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>