Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Cumbre Inc. and collaborator publish on a novel bacterial RNA polymerase inhibitor


Cumbre Inc. and University of Wisconsin-Madison research collaborator publish data on a new class of bacterial RNA polymerase inhibitor

Cumbre Inc., a privately held biopharmaceutical company, announced today the publication of a research paper in the October 24, 2003 issue of Science entitled "A new class of bacterial RNA polymerase inhibitor affects nucleotide addition." The paper describes the identification and characterization of the novel "CBR703" class of inhibitors through combined efforts in biochemistry, genetics and structural modeling with contributions from both Cumbre researchers and scientists from the University of Wisconsin-Madison.

Co-author Robert Landick, Ph.D., a Professor of Bacteriology at the University of Wisconsin-Madison, whose laboratory is primarily focused on studies of regulatory mechanisms that control gene expression in bacteria, commented, "The Cumbre RNA polymerase inhibitors are a major breakthrough. They give us a powerful new tool to study the mechanism of the central enzyme in the process of gene expression. At least as importantly, they also hold great promise for the development of new antibiotics that target bacterial pathogens, which is now a high-priority need in both medicine and bio-defense."

A. Simon Lynch, Ph.D., Cumbre’s Director of Research, added "We are excited about the development potential of the CBR703 series, and are pleased to be able to contribute to the RNA polymerase research community through provision of a novel experimental tool. We hope that ongoing efforts to determine high resolution X-ray structures of RNA polymerase-inhibitor complexes will both aid Cumbre’s antibiotic development program and yield additional insight regarding the fundamental processes underlying the transcription elongation cycle."

Cumbre, a privately held biopharmaceutical company founded in February 2001, is solely focused on the discovery, development, and commercialization of novel antibacterial therapeutics. Discovery programs combine unique target-directed biochemical screens with a novel cell-based approach. The most advanced development program is directed toward the optimization of a novel compound series for activity against pathogenic bacteria growing in the biofilm state.

Robert England | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife

nachricht Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Greater Range and Longer Lifetime

26.10.2016 | Power and Electrical Engineering

VDI presents International Bionic Award of the Schauenburg Foundation

26.10.2016 | Awards Funding

3-D-printed magnets

26.10.2016 | Power and Electrical Engineering

More VideoLinks >>>