Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer-killing viruses influence tumor blood-vessel growth

12.06.2008
Viruses genetically designed to kill cancer cells offer a promising strategy for treating incurable brain tumors such as glioblastoma, but the body's natural defenses often eliminate the viruses before they can eliminate the tumor.

The findings of an animal study by researchers at the Ohio State University Comprehensive Cancer Center help explain why this happens and could improve this therapy for brain cancer patients.

The research, published in the June 10 issue of the journal Molecular Therapy, shows that as the viruses destroy the tumor cells, they cause the cells to make proteins that stimulate the growth of new blood vessels to the tumor. These vessels transport immune cells that eradicate the viruses and actually stimulate regrowth of the tumor.

"This study points to an important side effect of oncolytic viral therapy that may limit its efficacy," says principal investigator Balveen Kaur, a researcher with Ohio State's Comprehensive Cancer Center and the Dardinger Laboratory for Neuro-oncology and Neurosciences.

... more about:
»CYR61 »Kaur »Viral »blood-vessel »glioma »oncolytic

"Knowing this, we can now work on designing a combination therapy that will inhibit this effect and enhance the action of the viral therapy."

The researchers also discovered that, in infected tumor cells, the viruses changed the activity levels of three genes linked to blood-vessel growth in gliomas.

One of these genes, CYR61, was nine times more active in virus-treated tumor cells than in uninfected tumors. The researchers also showed that the higher the dose of virus used, the greater the gene's activity.

For this study, Kaur and her colleagues implanted human glioma cells into rodents with a working immune system, then injected the resulting tumors of some with a cancer-killing, or oncolytic, virus called hrR3. The treated animals lived 17 days compared with 14 days for the untreated controls. The virus-treated tumors had roughly five times more blood vessels in them than the untreated tumors.

Treated tumors also showed changes in gene activity for three of 11 genes thought to play a role in blood-vessel development in gliomas. Of these, CYR61 showing an 8.9-fold increase in activity 12 hours after treatment.

Last, the researchers verified the virus-caused increase in CYR61 gene activity using several different glioma cell lines and glioma cells from patients, and several strains of active, replicating oncolytic viruses.

"In all cases, we observed a rise in CYR61 gene activity, which indicates that this change in gene activity may represent a host response to the viral infection," Kaur says. Non-replicating viruses had no affect on the gene's activity.

Kaur and her colleagues are now studying why cells turn on this gene when infected with oncolytic viruses and whether the protein that results from this gene activation might serve as a biomarker reflecting patients' response to oncolytic virus therapy.

"Measuring a patient's response to viral infection is currently not feasible," Kaur says, "so if this were to work, it would be a significant advance."

Darrell E. Ward | EurekAlert!
Further information:
http://www.osumc.edu

Further reports about: CYR61 Kaur Viral blood-vessel glioma oncolytic

More articles from Life Sciences:

nachricht Zap! Graphene is bad news for bacteria
23.05.2017 | Rice University

nachricht Discovery of an alga's 'dictionary of genes' could lead to advances in biofuels, medicine
23.05.2017 | University of California - Los Angeles

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Scientists propose synestia, a new type of planetary object

23.05.2017 | Physics and Astronomy

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>