The researchers have succeeded in neatly lining up proteins on a surface. The process also allows patterns of various types of proteins to be created. The proteins do not bind to the surface directly but via so-called ‘linkers’; these are molecules that organize themselves and create structure. This technology has interesting medical applications, as it allows the creation of a surface with antibodies - proteins that allow antigens to be detected in blood. The presence of antigens provides information about diseases or disease progression. Good detection relies entirely on highly specific binding. The odds of ‘incorrect’ bonds being formed is minimized by this new method.
Cells can also be bound to such a ‘protein printboard’ by using the characteristic proteins found on the outside of a cell. This cell adhesion is important in processes like counting immune cells – lymphocytes – to monitor the progression of an HIV infection. Highly specific binding is required to ensure reliable results. Thanks to the regular arrangement made possible by self-organization, researchers also achieve highly specific binding, minimizing the chances of errors. According to the researchers, this opens the door to low cost cell count systems.
The research was performed by the Molecular Nanofabrication (MESA+) and Biophysical Engineering (MESA+ and BMTI) groups. They cooperated with the Agrotechnology & Food Innovations group of the Wageningen University and Research Center.The article ‘Assembly of Bionanostructures onto ß-Cyclodextrin Molecular
Wiebe van der Veen | alfa
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
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Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
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In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
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COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
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'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
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