The researchers have succeeded in neatly lining up proteins on a surface. The process also allows patterns of various types of proteins to be created. The proteins do not bind to the surface directly but via so-called ‘linkers’; these are molecules that organize themselves and create structure. This technology has interesting medical applications, as it allows the creation of a surface with antibodies - proteins that allow antigens to be detected in blood. The presence of antigens provides information about diseases or disease progression. Good detection relies entirely on highly specific binding. The odds of ‘incorrect’ bonds being formed is minimized by this new method.
Cells can also be bound to such a ‘protein printboard’ by using the characteristic proteins found on the outside of a cell. This cell adhesion is important in processes like counting immune cells – lymphocytes – to monitor the progression of an HIV infection. Highly specific binding is required to ensure reliable results. Thanks to the regular arrangement made possible by self-organization, researchers also achieve highly specific binding, minimizing the chances of errors. According to the researchers, this opens the door to low cost cell count systems.
The research was performed by the Molecular Nanofabrication (MESA+) and Biophysical Engineering (MESA+ and BMTI) groups. They cooperated with the Agrotechnology & Food Innovations group of the Wageningen University and Research Center.The article ‘Assembly of Bionanostructures onto ß-Cyclodextrin Molecular
Wiebe van der Veen | alfa
Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel
The Nagoya Protocol Creates Disadvantages for Many Countries when Applied to Microorganisms
05.12.2016 | Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
05.12.2016 | Earth Sciences
05.12.2016 | Physics and Astronomy
05.12.2016 | Life Sciences