The researchers have succeeded in neatly lining up proteins on a surface. The process also allows patterns of various types of proteins to be created. The proteins do not bind to the surface directly but via so-called ‘linkers’; these are molecules that organize themselves and create structure. This technology has interesting medical applications, as it allows the creation of a surface with antibodies - proteins that allow antigens to be detected in blood. The presence of antigens provides information about diseases or disease progression. Good detection relies entirely on highly specific binding. The odds of ‘incorrect’ bonds being formed is minimized by this new method.
Cells can also be bound to such a ‘protein printboard’ by using the characteristic proteins found on the outside of a cell. This cell adhesion is important in processes like counting immune cells – lymphocytes – to monitor the progression of an HIV infection. Highly specific binding is required to ensure reliable results. Thanks to the regular arrangement made possible by self-organization, researchers also achieve highly specific binding, minimizing the chances of errors. According to the researchers, this opens the door to low cost cell count systems.
The research was performed by the Molecular Nanofabrication (MESA+) and Biophysical Engineering (MESA+ and BMTI) groups. They cooperated with the Agrotechnology & Food Innovations group of the Wageningen University and Research Center.The article ‘Assembly of Bionanostructures onto ß-Cyclodextrin Molecular
Wiebe van der Veen | alfa
Fingerprint' technique spots frog populations at risk from pollution
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Parallel computation provides deeper insight into brain function
27.03.2017 | Okinawa Institute of Science and Technology (OIST) Graduate University
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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