Wound closure and organ repair with nanoparticle solutions
Stopping bleeding, closing wounds, repairing organs—these are everyday challenges in medical and surgical practice. In the journal Angewandte Chemie, French researchers have now introduced a new method that employs gluing by aqueous nanoparticle solutions to effectively control bleeding and repair tissues. In animal tests, their approach proved easy to apply, rapid and efficient even in situations when conventional methods are traumatic or fail.
Sutures and staples are efficient tools for use in surgery and treating wounds. However, the usefulness of these methods can be limited in inaccessible parts of the body or in minimally invasive surgeries. In addition, stitching damages soft tissues such as liver, spleen, kidney, or lung.
A good adhesive could be a useful alternative. The problem is that the adhesion must take place in a wet environment and that the repaired area is immediately put under strain. Previous adhesive technologies have had problems, including insufficient strength, inflammation due to toxic substances, or complicated implementation because a chemical polymerization or cross-linking reaction must be carried out in a controlled manner.
A team headed by Ludwik Leibler at the Laboratoire Matière Molle et Chimie (CNRS/ESPCI Paris Tech) and Didier Letourneur at the Laboratoire Recherche Vasculaire Translationnelle (INSERM/Université Paris Diderot) has now successfully tested a completely novel approach for adhering living tissue: they simply apply droplets of a nanoparticle solution to the wound and press it closed for about a minute.
The principle behind is stunningly simple: the nanoparticles spread out across the surface and bind to the tissue’s molecular network by attracting interactions. Because there are a very large number of nanoparticles present, millions of bonds firmly bind the two surfaces together. No chemical reaction is needed. The researchers used silicon dioxide and iron oxide nanoparticles for their experiments.
In contrast to conventional wound adhesives, this results in no artificial barrier; it produces direct contact between the two edges of the wound. Because the nanoparticles are so small, they do not appreciably impact the wound healing process. Applied to deep skin wounds the method is easily usable and leads to remarkably aesthetic healing. In addition, it is possible to correct the positioning of the tissue edges relative to each other without opening the wound closure.
Aqueous solutions of nanoparticles have been also shown to be able to repair rapidly and efficiently in hemorrhagic conditions liver wounds for which sutures are traumatic and not practical. Either a wound was closed and wound edges were glued by nanoparticles or, in the case of liver resections, bleeding was quickly stopped by gluing a polymer strip using a nanoparticle solution.
In addition, the researchers were able to attach a biodegradable membrane to a beating rat heart. This opens new perspectives: it may be possible to attach medical devices for delivering drugs, supporting damaged tissue, as well as matrices for tissue growth.
About the Author
Dr. Ludwik Leibler is Research Director at Centre National de la Recherche Scientifique (CNRS) and director of Soft Matter and Chemistry laboratory at Ecole Supérieure de Physique et Chimie Industrielle (ESPCI ParisTech) in Paris, France and is working in the area of physics and chemistry of materials. He has received awards from various organizations including American Physical Society, American Chemical Society, French Academy of Sciences, French Chemical Society, and CNRS. He is a Foreign Associate of National Academy of Engineering (USA), of Die Nordrhein-Westfälische Akademie der Wissenschaften und der Künste, and a member of Academia Europaea.
Author: Ludwik Leibler, ESPCI ParisTech (France), http://www.espci.fr/en/directory?recherche=Ludwik%09Leibler&r_en_cours=on&type=recherche&unique_id=CgRcAjAeBDw%3D&lang=en
Title: Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles
Angewandte Chemie International Edition, Permalink to the article: http://dx.doi.org/10.1002/anie.201401043
Fingerprint' technique spots frog populations at risk from pollution
27.03.2017 | Lancaster University
Parallel computation provides deeper insight into brain function
27.03.2017 | Okinawa Institute of Science and Technology (OIST) Graduate University
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
27.03.2017 | Earth Sciences
27.03.2017 | Life Sciences
27.03.2017 | Life Sciences