A new study led by Professor Kui Liu at the University of Gothenburg has identified the key molecule ‘Greatwall kinase’ which protects women’s eggs against problems that can arise during the maturation process.
In order to be able to have a child, a woman needs eggs that can grow and mature. One of these eggs is then fertilised by a sperm, forming an embryo. During the maturation process, the egg needs to go through a number of stages of reductional division, called meiosis.
Kui Liu, professor, University of Gothenburg
University of Gothenburg
If problems occur during any of these stages, the woman can become infertile. Around 10-15% of all women experience fertility problems, caused by factors such as genetics, environment and age.
Human studies are the next stage
Using genetically modified mouse models, Professor Liu’s team has now discovered that the molecule Greatwall kinase is of great importance in order for the eggs of the female mouse to be able to complete the first phase and move on to the second meiotic division during the maturation of the egg.
When Greatwall kinase is removed from the egg, not all the stages can be completed. Instead, the egg enters an interphase with an abnormal DNA structure and problematic cell cycles. These problems make the females infertile.
Professor Liu believes it is highly likely that Greatwall kinase is important in the human egg maturation process. His group aims to carry out studies on human eggs as the next stage. The Greatwall kinase molecule is important in the regulation of the cell cycle.
“If we discover that there are women whose eggs do not mature due to levels of Greatwall kinase being too low, we can inject the molecule into the egg,” says Professor Liu. “Hopefully, the maturation process will thereby be corrected, and eventually the woman may be able to have children.”
Dr. Kui Liu is a professor at the University of Gothenburg’s Department of Chemistry and Molecular Biology. His group focuses on studies of genetic and epigenetic regulation of the development of female gametes.
In recent years, their research has included both preclinical basic research and transferring the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.
Link to the article: http://jcb.rupress.org/content/206/7/843.abstract
For further information:
Professor Kui Liu
+46 70 888 77 93
Henrik Axlid | idw - Informationsdienst Wissenschaft
Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main
Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Ecology, The Environment and Conservation
24.05.2018 | Medical Engineering
24.05.2018 | Physics and Astronomy