Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gothenburg researchers identify molecule that protects women's eggs

07.10.2014

A new study led by Professor Kui Liu at the University of Gothenburg has identified the key molecule ‘Greatwall kinase’ which protects women’s eggs against problems that can arise during the maturation process.

In order to be able to have a child, a woman needs eggs that can grow and mature. One of these eggs is then fertilised by a sperm, forming an embryo. During the maturation process, the egg needs to go through a number of stages of reductional division, called meiosis.


Kui Liu, professor, University of Gothenburg

University of Gothenburg

If problems occur during any of these stages, the woman can become infertile. Around 10-15% of all women experience fertility problems, caused by factors such as genetics, environment and age.

Human studies are the next stage

Using genetically modified mouse models, Professor Liu’s team has now discovered that the molecule Greatwall kinase is of great importance in order for the eggs of the female mouse to be able to complete the first phase and move on to the second meiotic division during the maturation of the egg.

When Greatwall kinase is removed from the egg, not all the stages can be completed. Instead, the egg enters an interphase with an abnormal DNA structure and problematic cell cycles. These problems make the females infertile.

Professor Liu believes it is highly likely that Greatwall kinase is important in the human egg maturation process. His group aims to carry out studies on human eggs as the next stage. The Greatwall kinase molecule is important in the regulation of the cell cycle.

“If we discover that there are women whose eggs do not mature due to levels of Greatwall kinase being too low, we can inject the molecule into the egg,” says Professor Liu. “Hopefully, the maturation process will thereby be corrected, and eventually the woman may be able to have children.”

Dr. Kui Liu is a professor at the University of Gothenburg’s Department of Chemistry and Molecular Biology. His group focuses on studies of genetic and epigenetic regulation of the development of female gametes.

In recent years, their research has included both preclinical basic research and transferring the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.

Link to the article: http://jcb.rupress.org/content/206/7/843.abstract

For further information:
Professor Kui Liu
+46 70 888 77 93
kui.liu@gu.se

Weitere Informationen:

http://www.science.gu.se/english/News/News_detail/gothenburg-researchers-identif...

Henrik Axlid | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>