Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

European research effort FUMINOMICS tackles dangerous mould

18.09.2008
Ubiquitous fungus Aspergillus fumigatus poses an increasing threat to patients with compromised immune systems

The European Science Foundation (ESF) has launched a new Research Networking Programme, FUMINOMICS, to study the basic genetic and molecular mechanisms employed by the fungus Aspergillus fumigatus when infecting host cells.

Infection with A. fumigatus is an increasing clinical problem and often has lethal consequences for patients with a compromised immune system. The four-year FUMINOMICS programme is supported by 7 contributing ESF member organisations* and involves most of the leading laboratories from several European countries. FUMINOMICS will be kicked-off with the workshop 'Transcriptomics and Molecular Tools' from 18-21 September in Giens, France.

Aspergillus fumigatus, a member of the large Aspergillus family of filamentous fungi (moulds), is an ubiquitous mould that lives in the soil and on plant debris and disperses its spores through the air. The mould is harmless to most people, but for those with a seriously diminished immune system, infection with A. fumigatus can be fatal. The group most at risk are people who have undergone organ (bone marrow) transplants and cancer treatment.

In this group, infection with A. fumigatus is often lethal, with mortality rates of 60-90% and occurs in 25 % of haematology patients. Diagnosis of invasive disease caused by A. fumigatus is difficult (it is often mistaken for pneumonia), as is the treatment of this type of infection.

Currently, A. fumigatus is already the most common cause of (clinical) mould infections worldwide. Harmless as the mould may be for persons with a normal defence system, there are still many cases known in which infections with A. fumigatus resulted in severe disease or even death in healthy individuals.

Until now, little is known of how A. fumigatus operates when infecting host cells. Considering the increasing clinical impact of the mould, fundamental research into its basic genetic mechanism is urgently needed. The ESF Research Networking Programme FUMINOMICS will tackle the basic questions surrounding gene expression and gene regulation of A. fumigatus through a multidisciplinary and fully integrated functional genomics approach that spans bioinformatics, transcriptomics, proteomics, physiology, molecular genetics and medicine.

Thomas Lau | alfa
Further information:
http://www.esf.org
http://www.esf.org/fuminomics

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>