Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

European research effort FUMINOMICS tackles dangerous mould

18.09.2008
Ubiquitous fungus Aspergillus fumigatus poses an increasing threat to patients with compromised immune systems

The European Science Foundation (ESF) has launched a new Research Networking Programme, FUMINOMICS, to study the basic genetic and molecular mechanisms employed by the fungus Aspergillus fumigatus when infecting host cells.

Infection with A. fumigatus is an increasing clinical problem and often has lethal consequences for patients with a compromised immune system. The four-year FUMINOMICS programme is supported by 7 contributing ESF member organisations* and involves most of the leading laboratories from several European countries. FUMINOMICS will be kicked-off with the workshop 'Transcriptomics and Molecular Tools' from 18-21 September in Giens, France.

Aspergillus fumigatus, a member of the large Aspergillus family of filamentous fungi (moulds), is an ubiquitous mould that lives in the soil and on plant debris and disperses its spores through the air. The mould is harmless to most people, but for those with a seriously diminished immune system, infection with A. fumigatus can be fatal. The group most at risk are people who have undergone organ (bone marrow) transplants and cancer treatment.

In this group, infection with A. fumigatus is often lethal, with mortality rates of 60-90% and occurs in 25 % of haematology patients. Diagnosis of invasive disease caused by A. fumigatus is difficult (it is often mistaken for pneumonia), as is the treatment of this type of infection.

Currently, A. fumigatus is already the most common cause of (clinical) mould infections worldwide. Harmless as the mould may be for persons with a normal defence system, there are still many cases known in which infections with A. fumigatus resulted in severe disease or even death in healthy individuals.

Until now, little is known of how A. fumigatus operates when infecting host cells. Considering the increasing clinical impact of the mould, fundamental research into its basic genetic mechanism is urgently needed. The ESF Research Networking Programme FUMINOMICS will tackle the basic questions surrounding gene expression and gene regulation of A. fumigatus through a multidisciplinary and fully integrated functional genomics approach that spans bioinformatics, transcriptomics, proteomics, physiology, molecular genetics and medicine.

Thomas Lau | alfa
Further information:
http://www.esf.org
http://www.esf.org/fuminomics

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
21.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Nagoya physicists resolve long-standing mystery of structure-less transition

21.08.2017 | Materials Sciences

Chronic stress induces fatal organ dysfunctions via a new neural circuit

21.08.2017 | Health and Medicine

Scientists from the MSU studied new liquid-crystalline photochrom

21.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>