Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

European research effort FUMINOMICS tackles dangerous mould

18.09.2008
Ubiquitous fungus Aspergillus fumigatus poses an increasing threat to patients with compromised immune systems

The European Science Foundation (ESF) has launched a new Research Networking Programme, FUMINOMICS, to study the basic genetic and molecular mechanisms employed by the fungus Aspergillus fumigatus when infecting host cells.

Infection with A. fumigatus is an increasing clinical problem and often has lethal consequences for patients with a compromised immune system. The four-year FUMINOMICS programme is supported by 7 contributing ESF member organisations* and involves most of the leading laboratories from several European countries. FUMINOMICS will be kicked-off with the workshop 'Transcriptomics and Molecular Tools' from 18-21 September in Giens, France.

Aspergillus fumigatus, a member of the large Aspergillus family of filamentous fungi (moulds), is an ubiquitous mould that lives in the soil and on plant debris and disperses its spores through the air. The mould is harmless to most people, but for those with a seriously diminished immune system, infection with A. fumigatus can be fatal. The group most at risk are people who have undergone organ (bone marrow) transplants and cancer treatment.

In this group, infection with A. fumigatus is often lethal, with mortality rates of 60-90% and occurs in 25 % of haematology patients. Diagnosis of invasive disease caused by A. fumigatus is difficult (it is often mistaken for pneumonia), as is the treatment of this type of infection.

Currently, A. fumigatus is already the most common cause of (clinical) mould infections worldwide. Harmless as the mould may be for persons with a normal defence system, there are still many cases known in which infections with A. fumigatus resulted in severe disease or even death in healthy individuals.

Until now, little is known of how A. fumigatus operates when infecting host cells. Considering the increasing clinical impact of the mould, fundamental research into its basic genetic mechanism is urgently needed. The ESF Research Networking Programme FUMINOMICS will tackle the basic questions surrounding gene expression and gene regulation of A. fumigatus through a multidisciplinary and fully integrated functional genomics approach that spans bioinformatics, transcriptomics, proteomics, physiology, molecular genetics and medicine.

Thomas Lau | alfa
Further information:
http://www.esf.org
http://www.esf.org/fuminomics

More articles from Life Sciences:

nachricht BigH1 -- The key histone for male fertility
14.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)

nachricht Guardians of the Gate
14.12.2017 | Max-Planck-Institut für Biochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Plasmonic biosensors enable development of new easy-to-use health tests

14.12.2017 | Health and Medicine

New type of smart windows use liquid to switch from clear to reflective

14.12.2017 | Physics and Astronomy

BigH1 -- The key histone for male fertility

14.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>