Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chemically Modified Insulin Is Available More Quickly

03.01.2017

Replacing a hydrogen atom by an iodine atom in insulin, the hormone retains its efficacy but is available more rapidly to the organism. Researchers at the University of Basel were able to predict this effect based on computer simulations and then confirm it with experiments. The results have been published in the Journal of Biological Chemistry.

Insulin is formed in the pancreas and regulates the blood glucose level. In the body it is stored as a zinc-bound complex of six identical molecules, called a hexamer. However, the physiologically active form is a single insulin monomer. Only when the body requires insulin the hexamer divides into monomers available for blood sugar regulation.


Binding of the insulin analog (green) to the receptor (light blue). The receptor’s surface is shown in transparent gray.

University of Basel, Department of Chemistry

Researchers attempt to control this disassembly process by developing artificial insulin preparations, in order to optimize clinical treatment of diabetes mellitus. By means of chemical modifications, the release and availability of insulin can be improved. One possible approach is to strategically replace individual atoms in a targeted manner. This results in what is known as an insulin analog, which differs from natural insulin in both structure and properties.

Artificial insulin is released more rapidly

The team led by Professor Markus Meuwly from the Department of Chemistry at the University of Basel has investigated this process in collaboration with researchers from the USA and Australia. The researchers exchanged a single hydrogen atom by an iodine atom which modulates intermolecular interactions that resulted in more rapid insulin disassembly and release.

Introducing the iodine atom improved the insulins’ availability, while the affinity for the insulin receptor and the biological function remained unchanged when compared to the natural hormone. These advantageous properties were first predicted by a combination of quantum chemistry and molecular dynamics simulations. In a next step, the stability changes of the chemically modified insulin were directly probed by using crystallographic and nuclear magnetic resonance experiments which confirmed the computations.

Clinical application possible

The use of halogen atoms is a promising approach for compound optimization in medicinal chemistry. The results obtained for iodinated insulin demonstrate that the concept of chemical modification has also great potential in the field of protein engineering. A future clinical application of the insulin analog, which differs from natural insulin by only a single atom, is quite conceivable.

Original source

Krystel El Hage, Vijay Pandyarajan, Nelson B. Phillips, Brian J. Smith, John G. Menting, Jonathan Whittaker, Michael C. Lawrence, Markus Meuwly, Michael A. Weiss
Extending Halogen-Based Medicinal Chemistry to Proteins: Iodo-Insulin as a Case Study
Journal of Biological Chemistry (2016), doi: 10.1074/jbc.M116.761015

Further information

Prof. Dr. Markus Meuwly, University of Basel, Department of Chemistry, Tel. +41 61 207 38 21, email: m.meuwly@unibas.ch

Weitere Informationen:

https://www.unibas.ch/en/News-Events/News/Uni-Research/Chemically-Modified-Insul...

Olivia Poisson | Universität Basel

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>