This was pointed out by Dr. Florian Siebzehnrubl (University of Florida College of Medicine, Gainesville, USA) on Friday, June 17, 2011, at the Brain Tumor Meeting in the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany.
In his presentation, Dr. Florian Siebzehnrubl from Professor Dennis Steindler’s laboratory illuminated the interaction between tumor stem cells and the extracellular matrix (ECM). The latter holds the tissue together and blocks the invasion of tumor cells. During the development of the nervous system, astrocytes form barriers mediated by the ECM. These immature astrocytes have similarities to neural stem cells.
“Cells that are similar to these immature astrocytes can also play a role in brain tumors,” Dr. Siebzehnrubl said. The reason is that these immature astrocytes are very similar to stem cells. Several years ago the Steindler lab was the first to discover cancer stem cells in glioblastoma, the most common and most aggressive form of brain tumors. The scientific consensus is that such tumor stem-like cells can initiate cancer and are also to blame for the fact that tumors can recur despite treatment.
“The ECM plays a key role in the development and spread of brain tumors,” Dr. Siebzehnrubl said, and he also presented new findings on a brain tumor cell that possesses a unique molecular profile (ZEB1) and which is involved in resistance to many current chemotherapeutics and thus involved in brain tumor recurrence.
A few years ago, the laboratory of Professor Helmut Kettenmann of the MDC in collaboration with the neurosurgeon Dr. Darko S. Markovic (Helios Klinikum Berlin-Buch) and Dr. Michael Synowitz (Charité – Universitätsmedizin Berlin) showed that microglia degrade the ECM by means of specific proteases, thus enabling glioblastomas to infiltrate the brain.
In a current study using animal models, Professor Steindler and his colleagues Dr. Siebzehnrubl and Dan Silver demonstrated that tumor cells that rapidly infiltrate tissue influence the molecular composition of the ECM differently than those that are less invasive. The researchers suspect that the change in behavior of the ECM may be due to the influence of tumor stem cells.
Therefore first studies are ongoing to modulate the ECM and other cancer-associated molecules so that brain tumors are cordoned off and brain tumor-initiating cells are less migratory, thus keeping them from infiltrating healthy brain tissue.Barbara Bachtler
Barbara Bachtler | Max-Delbrück-Centrum
Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo
Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Life Sciences
23.05.2018 | Life Sciences
23.05.2018 | Physics and Astronomy