Graphics of a complex which alongside Sirt5 contains a peptide with fluorophore as a substrate and resveratrol as an activator.
Graphics: Department of Biochemistry, University of Bayreuth; free for publication when references are included.
So why do resveratrol / piceatannol have these opposing effects on Sirt5 and Sirt3? The researchers do not have a definitive answer, but they do have a first idea. The interactions resveratrol / piceatannol forms to the sirtuin on the one hand and to the peptide on the other hand lead to a slightly different peptide arrangement in Sirt3 when compared to Sirt5. The positioning of the substrate is crucial for the deacetylation; even a small change can therefore slow down Sirt3, but also speed up Sirt5.
The effect of resveratrol on the sirtuin depends on the substrate
Christian Wißler | Universität Bayreuth
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