The project aims at implementing a novel multidisciplinary approach to investigate the requirements, at the molecular-structure level, for viable (bactericidal) candidates for vaccine assays and developing bioinformatics tools to predict compliance with such requirements, starting from information generated in previous projects by members of the consortium.
High throughput cloning and expression of large sets of genomic ORFs has become a preferred industrial strategy for genome-wide searches of new vaccine candidates. For invasive infections in particular, the aim is to find proteins eliciting antibodies capable of binding to the bacterial cell surface and, through interaction with the complement system, effectively kill the bacteria. However, current data accumulating from reverse vaccinology studies (targeting of possible vaccine candidates starting from genomic information) show that only a small fraction of surface-exposed proteins appears to elicit antibodies with bactericidal activity.
The BacAbs project will undertake a systematic analysis of sequence, structure, dynamics and interactions of selected protein targets using as model system serogroup-B Neisseria meningitidis, a pathogen causing septicemia and meningitis for which no effective vaccine exists.
The Consortium comprises an industrial partner with extensive experience on vaccine development –Novartis Vaccines and Diagnostics, Italy-, three small or medium enterprises with strong expertises on several of the key technological aspects of the project –ASLA Biotech, Latvia; Bio-Xtal, France; INFOCIENCIA, Spain), and five academic partners with groups having internationally recognized tracks on experimental and theoretical studies of protein structure and interactions (Universitat Autònoma de Barcelona, Spain; Consiglio Nazionale delle Ricerche, Italy; International University Bremen, Germany; Università degli Studi di Milano, Italy; Universiteit Utrecht, Netherlands).
With a duration of three years, the project is supported by funding under the Sixth Research Framework Programme of the European Union.
Octavi López Coronado | alfa
Lego-like wall produces acoustic holograms
17.10.2016 | Duke University
New evidence on terrestrial and oceanic responses to climate change over last millennium
11.10.2016 | University of Granada
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
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