The project aims at implementing a novel multidisciplinary approach to investigate the requirements, at the molecular-structure level, for viable (bactericidal) candidates for vaccine assays and developing bioinformatics tools to predict compliance with such requirements, starting from information generated in previous projects by members of the consortium.
High throughput cloning and expression of large sets of genomic ORFs has become a preferred industrial strategy for genome-wide searches of new vaccine candidates. For invasive infections in particular, the aim is to find proteins eliciting antibodies capable of binding to the bacterial cell surface and, through interaction with the complement system, effectively kill the bacteria. However, current data accumulating from reverse vaccinology studies (targeting of possible vaccine candidates starting from genomic information) show that only a small fraction of surface-exposed proteins appears to elicit antibodies with bactericidal activity.
The BacAbs project will undertake a systematic analysis of sequence, structure, dynamics and interactions of selected protein targets using as model system serogroup-B Neisseria meningitidis, a pathogen causing septicemia and meningitis for which no effective vaccine exists.
The Consortium comprises an industrial partner with extensive experience on vaccine development –Novartis Vaccines and Diagnostics, Italy-, three small or medium enterprises with strong expertises on several of the key technological aspects of the project –ASLA Biotech, Latvia; Bio-Xtal, France; INFOCIENCIA, Spain), and five academic partners with groups having internationally recognized tracks on experimental and theoretical studies of protein structure and interactions (Universitat Autònoma de Barcelona, Spain; Consiglio Nazionale delle Ricerche, Italy; International University Bremen, Germany; Università degli Studi di Milano, Italy; Universiteit Utrecht, Netherlands).
With a duration of three years, the project is supported by funding under the Sixth Research Framework Programme of the European Union.
Octavi López Coronado | alfa
A new method for the 3-D printing of living tissues
16.08.2017 | University of Oxford
Bergamotene - alluring and lethal for Manduca sexta
21.04.2017 | Max-Planck-Institut für chemische Ökologie
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
21.08.2017 | Medical Engineering
21.08.2017 | Materials Sciences
21.08.2017 | Life Sciences