Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UAB coordinates a European project on vaccine research

05.03.2007
The STREP research project "Assessment of Structural Requirements in Complement-Mediated Bactericidal Events: Towards a Global Approach to the Selection of New Vaccine Candidates1, –BacAbs" has been recently launched by a consortium of nine institutions –academic and industrial- from six European countries, coordinated by Xavier Daura, ICREA Research Professor at the Institute of Biotechnology and Biomedicine of UAB.

The project aims at implementing a novel multidisciplinary approach to investigate the requirements, at the molecular-structure level, for viable (bactericidal) candidates for vaccine assays and developing bioinformatics tools to predict compliance with such requirements, starting from information generated in previous projects by members of the consortium.

High throughput cloning and expression of large sets of genomic ORFs has become a preferred industrial strategy for genome-wide searches of new vaccine candidates. For invasive infections in particular, the aim is to find proteins eliciting antibodies capable of binding to the bacterial cell surface and, through interaction with the complement system, effectively kill the bacteria. However, current data accumulating from reverse vaccinology studies (targeting of possible vaccine candidates starting from genomic information) show that only a small fraction of surface-exposed proteins appears to elicit antibodies with bactericidal activity.

The BacAbs project will undertake a systematic analysis of sequence, structure, dynamics and interactions of selected protein targets using as model system serogroup-B Neisseria meningitidis, a pathogen causing septicemia and meningitis for which no effective vaccine exists.

The Consortium comprises an industrial partner with extensive experience on vaccine development –Novartis Vaccines and Diagnostics, Italy-, three small or medium enterprises with strong expertises on several of the key technological aspects of the project –ASLA Biotech, Latvia; Bio-Xtal, France; INFOCIENCIA, Spain), and five academic partners with groups having internationally recognized tracks on experimental and theoretical studies of protein structure and interactions (Universitat Autònoma de Barcelona, Spain; Consiglio Nazionale delle Ricerche, Italy; International University Bremen, Germany; Università degli Studi di Milano, Italy; Universiteit Utrecht, Netherlands).

With a duration of three years, the project is supported by funding under the Sixth Research Framework Programme of the European Union.

Octavi López Coronado | alfa
Further information:
http://www.uab.es

More articles from Interdisciplinary Research:

nachricht 36 big data research projects
21.02.2017 | Schweizerischer Nationalfonds SNF

nachricht Coastal wetlands excel at storing carbon
01.02.2017 | University of Maryland

All articles from Interdisciplinary Research >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>