The Cambridge-MIT Institute (CMI) is today launching a new initiative to unite biologists and medical researchers with physicists, engineers, computer scientists and mathematicians to work on an innovative approach to discovering the next generation of drugs.
CMI is funding a transatlantic Next-Generation Drug Discovery Community that will bring together researchers at Cambridge University and the Massachusetts Institute of Technology (MIT) with partners from the IT, pharmaceutical and biotechnology industries. They will be working on new methods of tackling the urgent and severe bottlenecks in the discovery and development of new drugs - particularly drugs for diseases with complex causes such as cancers, arthritis, multiple sclerosis, and diabetes.
Drug discovery is currently an extremely lengthy and costly process. On average, it takes new treatments $800m and twelve years to reach the market - and those are just the ones that succeed. But the sequencing of the human genome has made available a vast array of information about the many, very complex ways in which the human body works.
“Our aims are to develop safer and more effective new drugs, faster and cheaper,” says Professor Lauffenburger from MIT. “Another aim of this Community is reduce the current reliance on animal experiments to predict effects on humans.”
As part of its work, the Community is conducting two research projects. One is studying adult, blood stem cells with the aim of using them to establish new experimental systems to test the efficacy and toxicity of drugs on human physiology. The other project aims to establish new, computational methods by which drug targets can be identified from human gene- and protein-level data.
“There are major computational challenges involved,” says Dr Gos Micklem, who is part of the Cambridge team, “if we are going to make sense of all the data, and use it to start building systems-level views of life and disease processes. As we start to do this, and take into account the genetic variation between individuals, this opens up new possibilities in evaluating disease susceptibility, improved diagnosis and the ability to offer therapy tailored to each individual patient.”
The Next-Generation Drug Discovery Community is one of several new Knowledge Integration Communities (KICs) that the Cambridge-MIT Institute is setting up. These KICs aim to find new ways in which academia and industry can work together and exchange knowledge to push forward research in areas where UK industry has a demonstrable competitive position – like biotechnology and information technology . So alongside the research work, there are other strands to the Community. New educational programmes are being created. These include a new Masters degree programme at the University of Cambridge, an MPhil in Computational Biology, to teach biology to mathematicians and others, and make biologists more familiar with computer science.
Meanwhile, industry is also being informed about this work, and encouraged to join the Community.
Dr Adriano Henney, Director in Global Sciences & Information at AstraZeneca, says, “AstraZeneca, through its collaboration with MIT, already recognises the potential value of systems biology and mathematical modelling. During this collaboration, the joint project teams have prototyped the use of these approaches in drug discovery and this has helped to influence investment in the creation of a new, multidisciplinary capability in this area within the Company. We are looking forward to continuing our close collaboration with Professor Lauffenburger, and to the possibility of extending this to include Cambridge in the near future.”
Lize King | alfa
Investigating cell membranes: researchers develop a substance mimicking a vital membrane component
25.05.2018 | Westfälische Wilhelms-Universität Münster
New approach: Researchers succeed in directly labelling and detecting an important RNA modification
30.04.2018 | Westfälische Wilhelms-Universität Münster
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
15.06.2018 | Materials Sciences
15.06.2018 | Ecology, The Environment and Conservation
15.06.2018 | Power and Electrical Engineering