The European Molecular Biology Laboratory (EMBL) has developed a new computational tool that makes images obtained with cutting-edge microscopes even sharper. The technological advance and its applications are published in this week’s online issue of the journal Nature Methods.
Since the Single Plane Illumination Microscope (SPIM) was developed at EMBL in the early 2000s it has turned into one of the most powerful tools in cell biology. SPIM allows scientists to study large, living specimen along many different angles, under real conditions and with minimal harm to the specimen. Snapshots of the specimen obtained in different planes along different directions and at varying time points are assembled into three-dimensional images or movies, which provide insights into the dynamic cellular processes of a living organism.
A deconvolution algorithm developed and applied by Peter Verveer and Ernst Stelzer and his group at EMBL now greatly improves the resolution of SPIM. This development provides new opportunities for studying sub-cellular processes in large living specimen. SPIM will also likely allow studies of live tissue under physiological conditions paving the way for the use of modern cell biology in clinically relevant research.
Anna-Lynn Wegener | alfa
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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