By training professionals in high-biodiversity regions to advance the drug discovery process in-country, a novel program drives drug discovery costs down as it promotes tropical biodiversity conservation. An international team describes a successful test of the program in Panama in the December, 2006 issue of BioScience.
"Instead of sending samples to the U.S. or Switzerland, we identify natural substances that may control cancer, AIDS, malaria and other tropical diseases here, at the University of Panama," explains Luis Cubilla-Rios, one of the chemists on the project. Over 70 Panamanian students participated during the first seven years of the project, and 22 continue to seek graduate degrees in the sciences.
Phyllis Coley and Tom Kursar, University of Utah, studied basic chemical ecology of plants at the Smithsonian Tropical Research Institute's station on Barro Colorado Island in Panama: "We were alarmed by the lack of conservation strategies that provide immediate benefits for people living in high biodiversity regions," explains Kursar, who sought funding for this project, called the International Cooperative Biodiversity Groups (ICBG) from the U.S. National Institutes of Health, the National Science Foundation, and the Department of Agriculture.
"By making it feasible for host country professionals to conduct as much of the drug discovery process as possible in Panama , the ICBG program provides immediate economic and educational benefits," Coley emphasizes.
"Only a small proportion of bioactive substances make it to the product development stage. If that happens, the proceeds come back to Panama…but the success of this project doesn't depend on that happening. Also, research on malaria, leishmaniasis, dengue and Chagas disease is of great national importance, even though treatments for such diseases are unlikely to generate large financial benefits," adds Todd Capson, the in-country program coordinator, who worked closely with Panama's Environment Authority (ANAM), the University of Panama, Gorgas Laboratories and the National Office of Science and Technology (SENACYT) to establish the institutional framework for the project.
Now technology transfer goes from South to North. In addition to describing potential pharmaceutical chemicals, and developing innovative bioassay procedures, local professionals become successful advocates for increased protection for areas such as Coiba National Park, which became a World Heritage Site based on scientific documentation of its marine and terrestrial biodiversity.
Kursar sums up the program this way: "We document biodiversity, provide scientific training and jobs and level the playing field, encouraging the establishment of truly international, multidisciplinary scientific collaborations."
"The ICBG program is an example of the practical application of basic research for human benefit. Ecologists know who eats whom and understand chemical signalling—without them, drug discovery teams would be faced with the difficult task of looking for a needle in a haystack," STRI Director, Ira Rubinoff concludes.
Upcycling 'fast fashion' to reduce waste and pollution
03.04.2017 | American Chemical Society
Litter is present throughout the world’s oceans: 1,220 species affected
27.03.2017 | Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
24.04.2017 | Physics and Astronomy
24.04.2017 | Materials Sciences
24.04.2017 | Life Sciences