By training professionals in high-biodiversity regions to advance the drug discovery process in-country, a novel program drives drug discovery costs down as it promotes tropical biodiversity conservation. An international team describes a successful test of the program in Panama in the December, 2006 issue of BioScience.
"Instead of sending samples to the U.S. or Switzerland, we identify natural substances that may control cancer, AIDS, malaria and other tropical diseases here, at the University of Panama," explains Luis Cubilla-Rios, one of the chemists on the project. Over 70 Panamanian students participated during the first seven years of the project, and 22 continue to seek graduate degrees in the sciences.
Phyllis Coley and Tom Kursar, University of Utah, studied basic chemical ecology of plants at the Smithsonian Tropical Research Institute's station on Barro Colorado Island in Panama: "We were alarmed by the lack of conservation strategies that provide immediate benefits for people living in high biodiversity regions," explains Kursar, who sought funding for this project, called the International Cooperative Biodiversity Groups (ICBG) from the U.S. National Institutes of Health, the National Science Foundation, and the Department of Agriculture.
"By making it feasible for host country professionals to conduct as much of the drug discovery process as possible in Panama , the ICBG program provides immediate economic and educational benefits," Coley emphasizes.
"Only a small proportion of bioactive substances make it to the product development stage. If that happens, the proceeds come back to Panama…but the success of this project doesn't depend on that happening. Also, research on malaria, leishmaniasis, dengue and Chagas disease is of great national importance, even though treatments for such diseases are unlikely to generate large financial benefits," adds Todd Capson, the in-country program coordinator, who worked closely with Panama's Environment Authority (ANAM), the University of Panama, Gorgas Laboratories and the National Office of Science and Technology (SENACYT) to establish the institutional framework for the project.
Now technology transfer goes from South to North. In addition to describing potential pharmaceutical chemicals, and developing innovative bioassay procedures, local professionals become successful advocates for increased protection for areas such as Coiba National Park, which became a World Heritage Site based on scientific documentation of its marine and terrestrial biodiversity.
Kursar sums up the program this way: "We document biodiversity, provide scientific training and jobs and level the playing field, encouraging the establishment of truly international, multidisciplinary scientific collaborations."
"The ICBG program is an example of the practical application of basic research for human benefit. Ecologists know who eats whom and understand chemical signalling—without them, drug discovery teams would be faced with the difficult task of looking for a needle in a haystack," STRI Director, Ira Rubinoff concludes.
Global threat to primates concerns us all
19.01.2017 | Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung
Reducing household waste with less energy
18.01.2017 | FIZ Karlsruhe – Leibniz-Institut für Informationsinfrastruktur GmbH
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences