Considered the power generators of the cell, mitochondria convert oxygen and nutrients into chemical energy for the cell that fuels metabolic activities.
Mitochondrial dysfunction has been associated with many diseases, including Alzheimer's, cancer and diabetes, although its exact role in the development of these diseases remains controversial.
The new T-R01 program was specifically created under the NIH Roadmap for Medical Research to support exceptionally innovative, high risk, original or unconventional research projects that have the potential to transform a field of science. The selected projects tend to be inherently risky, but if successful, can profoundly impact a broad area of biomedical research.
Cohen’s bold proposal will test the paradigm-shifting hypothesis that previously unrecognized molecules, he dubbed “mitochondrial-derived peptides” (MDPs), play an earlier unappreciated role in the regulation of cellular and organismal function, and that disregulation of MDPs is important in disease development.
Likewise, understanding the role of MDPs may lead to development of new therapeutic and diagnostic targets. Since Alzheimer’s, cancer and diabetes particularly affect the elderly, these findings could have a significant impact as the world’s aging population continues to grow. The first of these agents, which Cohen named “small humanin-like peptides,” have already demonstrated promise in animal models of diabetes and cancer.
Cohen was one of only 42 researchers nationwide chosen for the T-R01 award. He also serves as chief of endocrinology at the Mattel Children's Hospital UCLA, as well as co-director of the UCSD/UCLA Diabetes and Endocrinology Research Center.
For more information on Cohen, research plans please visit http://nihroadmap.nih.gov/T-R01/Recipients09.asp
Innovation Award of the United Nations Environment Programme for PhD Student from ZMT
22.03.2018 | Leibniz-Zentrum für Marine Tropenforschung (ZMT)
ERC Project set to boost application of adhesive structures
19.03.2018 | INM - Leibniz-Institut für Neue Materialien gGmbH
At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.
Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
25.04.2018 | Physics and Astronomy
25.04.2018 | Physics and Astronomy
25.04.2018 | Information Technology