Considered the power generators of the cell, mitochondria convert oxygen and nutrients into chemical energy for the cell that fuels metabolic activities.
Mitochondrial dysfunction has been associated with many diseases, including Alzheimer's, cancer and diabetes, although its exact role in the development of these diseases remains controversial.
The new T-R01 program was specifically created under the NIH Roadmap for Medical Research to support exceptionally innovative, high risk, original or unconventional research projects that have the potential to transform a field of science. The selected projects tend to be inherently risky, but if successful, can profoundly impact a broad area of biomedical research.
Cohen’s bold proposal will test the paradigm-shifting hypothesis that previously unrecognized molecules, he dubbed “mitochondrial-derived peptides” (MDPs), play an earlier unappreciated role in the regulation of cellular and organismal function, and that disregulation of MDPs is important in disease development.
Likewise, understanding the role of MDPs may lead to development of new therapeutic and diagnostic targets. Since Alzheimer’s, cancer and diabetes particularly affect the elderly, these findings could have a significant impact as the world’s aging population continues to grow. The first of these agents, which Cohen named “small humanin-like peptides,” have already demonstrated promise in animal models of diabetes and cancer.
Cohen was one of only 42 researchers nationwide chosen for the T-R01 award. He also serves as chief of endocrinology at the Mattel Children's Hospital UCLA, as well as co-director of the UCSD/UCLA Diabetes and Endocrinology Research Center.
For more information on Cohen, research plans please visit http://nihroadmap.nih.gov/T-R01/Recipients09.asp
Radio astronomers score high marks in the competition for EU funding
12.01.2017 | Max-Planck-Institut für Radioastronomie
Europe wide cooperation on spinal cord injury research receives 1.34 Million Euros grant
12.12.2016 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
18.01.2017 | Materials Sciences
18.01.2017 | Information Technology
18.01.2017 | Ecology, The Environment and Conservation