They received the prize, worth 10,000 euros, on July 4, 2008 in Berlin for their findings published in Nature Immunology* from Professor Peter Schlag, president of the Berlin Cancer Society (Charité, MDC). Hodgkin's lymphoma, a common form of cancer of the lymphatic system, originates from white blood cells (B cells), which alter their phenotype completely and thus lose all characteristics of a B cell.
Dr. Janz and Dr. Mathas succeeded in decoding the camouflage mechanisms of B cells. Based on these findings, cancer researchers hope that therapy strategies can be developed that will lead to an inhibition of cell growth or to apoptosis of the Hodgkin cells.
The phenotype of Hodgkin lymphoma cells is a riddle that has puzzled pathologists for years. It was not until 1994, some 160 years after the disease was first described by the British physician Sir Thomas Hodgkin (1832), that - using molecular biological methods - scientists discovered that the lymphoma bearing his name originates from the white blood cells, the B cells.
In their article, Dr. Janz and Dr. Mathas of the research group of Professor Bernd Dörken (MDC/Charité) were able to show that several molecular defects in the B cells are responsible for the unique phenotype of the disease. First, in Hodgkin/Reed-Sternberg cells which have evolved from the B cells, the genetic program that steers the maturation of the B cells and maintains their identity is perturbed. One of the main regulators of this program, E2A, is inhibited in Hodgkin lymphoma cells by two antagonists, Id2 and ABF-1. The researchers showed that this mechanism inhibits the gene expression pattern of B cells. Moreover, through the inhibition of E2A in Hodgkin lymphoma cells, genes are switched on that are not typical for B cell development.
Since 1988, the Curt Meyer Memorial Prize has been awarded annually by the Berlin Cancer Society to young scientists from Berlin for outstanding publications in the field of clinical and experimental oncology. The prize is named after Dr. Curt Meyer, a physician and health official of the Berlin Senate who was born in Herleshausen/Thuringia in 1891. In 1944, he was deported to Auschwitz where he as prisoner took care of fellow detainees suffering from epidemic disease. He survived the concentration camp and after the war dedicated himself to public health, including the care of cancer patients. He was the founder of several medical societies, including the Berlin State Committee against Cancer out of which the Berlin Cancer Society has evolved. Curt Meyer died in 1984 at the age of 93.
*Intrinsic inhibition of E2A by ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
Stephan Mathas1,2*, Martin Janz1,2*, Franziska Hummel2, Michael Hummel3, Brigitte Wollert-Wulf2, Simone Lusatis2 , Ioannis Anagnosto-poulos3, Andreas Lietz2, Mikael Sigvardsson4, Franziska Jundt1,2, Korinna Jöhrens3, Kurt Bommert2, Harald Stein3 and Bernd Dörken1,2
1Max Delbrück Center for Molecular Medicine, Robert-Rossle-Str. 10, 13125 Berlin; 2Hematology, Oncology and Tumorimmunology, Charite, Medical University Berlin, Campus Virchow-Klinikum, Campus Berlin-Buch, Augustenburger Platz 1, 13353 Berlin; 3Institute for Pathology, Charite, Medical University Berlin, Campus Benjamin Franklin, 12200 Berlin; 4Department for Hematopoietic Stemcell Biology, Stemcell Center, Lund University, S221 84 Lund, Sweden*These authors contributed equally to this work
Barbara Bachtler | idw
Extensive Funding for Research on Chromatin, Adrenal Gland, and Cancer Therapy
28.06.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Otto Hahn Medal for Jaime Agudo-Canalejo
21.06.2017 | Max-Planck-Institut für Kolloid- und Grenzflächenforschung
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
28.06.2017 | Physics and Astronomy
28.06.2017 | Physics and Astronomy
28.06.2017 | Health and Medicine