Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Funding boost in fight against leukaemia

University of Manchester researchers have been awarded £1.6 million to study a group of genes identified as playing a key role in leukaemia.

The grant, by Leukaemia Research, will fund work analysing a wide range of cancer-causing genes in the hope of targeting their common mechanisms of action for patient benefit.

“All cancers and leukaemias occur because of mutations in certain genes that stop them functioning properly,” said Tony Whetton, Professor of Cancer Cell Biology and research leader.

“Mutations in a group of genes leads to unregulated activity in a group of proteins called tyrosine kinases, which change the actions of other proteins, leading to leukaemia.”

The team are using state-of-the-art equipment to discover whether the different leukaemia-associated kinases contribute to the disease in the same way; if they do, it offers the opportunity to develop common therapies to block their actions.

“This would potentially be effective for many different types of leukaemia because the mutated kinase genes we are studying occur in several types of blood and bone marrow cancers,” said Professor Whetton, who is Head of the School of Cancer and Imaging Sciences.

“What is also exciting is that there are already drugs that are able to block the actions of kinases. These kinase inhibitor drugs are attracting worldwide attention as a new form of treatment for certain cancers including some leukaemias. We hope to add further leukaemias to this list by understanding more fully what this range of kinases do.”

Leukaemia Research currently provides more than £3.6 million in funding to the School of Cancer and Imaging Sciences, complementing ongoing research in other areas of the Manchester Cancer Research Centre (MCRC) alliance between the University and the Christie Trust.

This alliance has had a synergistic effect on cancer research in Manchester by promoting cross-disciplinary collaborations and attracting new funding from government, industry and charities.

Professor Whetton said: “In the past few years we have developed a multidisciplinary research approach, employing the latest cutting-edge technologies to take basic research towards clinical relevance as swiftly as possible”.

“In so doing, we have built a research platform that not only enables leukaemia research but cancer research in general on the Christie Hospital NHS Foundation Trust site.”

Aeron Haworth | alfa
Further information:

More articles from Awards Funding:

nachricht Changing the Energy Landscape: Affordable Electricity for All
20.10.2016 | Fraunhofer-Institut für Solare Energiesysteme ISE

nachricht Emmy Noether junior research group investigates new magnetic structures for spintronics applications
11.10.2016 | Johannes Gutenberg-Universität Mainz

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>