The grant will allow Dr. Kevin G. Pinney, professor of chemistry and biochemistry in Baylor’s College of Arts and Sciences, and Dr. Mary Lynn Trawick, an associate professor of chemistry and biochemistry, to design, create and test several new potential new cancer fighting compounds that may disrupt solid-cancer tumors and target any remaining tumor cells that may grow after the tumor is treated. The work will be done in collaboration with University of Texas Southwestern Medical Center in Dallas, who will serve as a subcontract on the grant award.
“We are one of the few programs in the world working with these particular compounds and with the collaboration with UT Southwestern, I think this research project was very attractive to NIH,” Pinney said. “This project will give us some deeper insight into these compounds that, in the future, might lead to clinical trials.”
In the first phase of the research, Pinney and Trawick will test three new compounds known as Vascular Disrupting Agents (VDA) that have shown promise in preliminary tests. An emerging area of cancer treatment still in the experimental phase, VDAs target the flow of blood to solid cancer tumors and other abnormal blood vessels while leaving healthy cells intact. The researchers will test these three compounds to see how tolerable they are in animal models and how well the compounds actually disrupt blood flow to the tumor.
The second phase will consist of designing, creating and testing a carefully selected small group of potential new cancer fighting compounds that may disrupt solid-cancer tumors. The Baylor researchers said the main point of emphasis will be on the mechanism of action of the new compounds. Pinney and his research team will be involved with the synthesis and purification of the new potential anticancer VDAs, while Trawick and her research team will evaluate the biochemistry and cell biology.
Finally, the third phase will look into the cell mechanisms of each of the new compounds. The Baylor researchers said many questions remain unanswered, to date, in regard to how VDAs actually function on a molecular level in terms of cell signaling pathways. The study will look at several of these mechanistic questions.
“We will be comparing and studying the cells and proteins to see just how potent they are to cancer which could eventually lead to new drug discovery,” Trawick said. “We are looking at selectivity – how do they disrupt cancer tumors and how well do they do it.”
The study will take about five years to complete.For more information, contact Matt Pene, assistant director of media communications, at (254) 710-4656.
Matt Pene | Newswise Science News
Otto Hahn Medal for Jaime Agudo-Canalejo
21.06.2017 | Max-Planck-Institut für Kolloid- und Grenzflächenforschung
Call for nominations of outstanding catalysis researchers for the Otto Roelen Medal 2018
20.06.2017 | DECHEMA Gesellschaft für Chemische Technik und Biotechnologie e.V.
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
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13.06.2017 | Event News
23.06.2017 | Physics and Astronomy
23.06.2017 | Physics and Astronomy
23.06.2017 | Information Technology