Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

EU funds research project on intestinal immune processes

17.01.2014
HZI researcher receives ERC Starting Grant

How do bacteria, the intestinal surface and the immune system interact with each other?

Dr Till Strowig from the Helmholtz Centre for Infection Research (HZI) in Braunschweig wants to tackle this question in a joint project with the University Medical Center Hamburg-Eppendorf. Using the body’s own molecule Interleukin 22, he will analyse this complex interplay.

The European Research Council ERC will support the project for the next five years with an ERC Starting Grant of 1.5 million Euro in total. The researchers hope to gain new insights regarding the development of colon cancer and other chronic intestinal illnesses.

The human colon offers an ideal habitat for a variety of bacteria. The number and composition of microbe species differ significantly from one person to the next. This individual microbiome is influenced by factors such as diet and activity of the immune system, but also by the intake of certain drugs, like antibiotics. It significantly affects the function of the intestinal mucosa and its immune responses.

The messenger Interleukin 22 and its antagonist, the Interleukin 22-binding protein, are crucial when it comes to immune reactions and tissue regeneration, as for example in wound healing. Mice which cannot produce Interleukin 22 or its antagonist exhibit a significantly higher colon cancer risk compared to animals producing these proteins.

“We want to find out how these two factors are regulated,” says Till Strowig. “Our main interest is to identify the bacteria in the intestinal flora and the cells of the immune system which are involved.” Whereas he will mainly investigate the interplay between colon bacteria and epithelium, his colleague, Prof Samuel Huber from the University Medical Center Hamburg-Eppendorf, will focus on the relation between immune cells and epithelium. A better understanding of the different cell types responsible for tissue regeneration and immune responses could lead to the development of new therapies against chronic intestinal illnesses and colon cancer.

Till Strowig completed the Medical Biotechnology programme at the “Technische Universität” Berlin. He wrote his diploma thesis at the Rockefeller University in New York, where he later finished his PhD, funded by the Boehringer Ingelheim Foundation. Afterwards, Strowig continued his research at Yale University. Since June 2013, he is head of the junior research group Microbial Immune Regulation at the HZI.

The ERC Starting Grant is awarded annually by the European Research Council to outstanding talents from all scientific fields (http://erc.europa.eu/starting-grants). The main criterion for ERC funding is scientific excellence of the proposed research.

The “Microbial Immune Regulation” Junior Research Group investigates the functions of the microbiome and how it affects the development of infectious diseases.

The Helmholtz Centre for Infection Research
Scientists at the Helmholtz Centre for Infection Research in Braunschweig, Germany, are engaged in the study of different mechanisms of infection and of the body’s response to infection. Helping to improve the scientific community’s understanding of a given bacterium’s or virus’ pathogenicity is key to developing effective new treatments and vaccines.

http://www.helmholtz-hzi.de

Weitere Informationen:
EU funds research project on intestinal immune processes
Dr. Ulrike Lampe Presse- und Öffentlichkeitsarbeit
Helmholtz-Zentrum für Infektionsforschung
HZI researcher receives ERC Starting Grant
How do bacteria, the intestinal surface and the immune system interact with each other? Dr Till Strowig from the Helmholtz Centre for Infection Research (HZI) in Braunschweig wants to tackle this question in a joint project with the University Medical Center Hamburg-Eppendorf. Using the body’s own molecule Interleukin 22, he will analyse this complex interplay. The European Research Council ERC will support the project for the next five years with an ERC Starting Grant of 1.5 million Euro in total. The researchers hope to gain new insights regarding the development of colon cancer and other chronic intestinal illnesses.

The human colon offers an ideal habitat for a variety of bacteria. The number and composition of microbe species differ significantly from one person to the next. This individual microbiome is influenced by factors such as diet and activity of the immune system, but also by the intake of certain drugs, like antibiotics. It significantly affects the function of the intestinal mucosa and its immune responses.

The messenger Interleukin 22 and its antagonist, the Interleukin 22-binding protein, are crucial when it comes to immune reactions and tissue regeneration, as for example in wound healing. Mice which cannot produce Interleukin 22 or its antagonist exhibit a significantly higher colon cancer risk compared to animals producing these proteins.

“We want to find out how these two factors are regulated,” says Till Strowig. “Our main interest is to identify the bacteria in the intestinal flora and the cells of the immune system which are involved.” Whereas he will mainly investigate the interplay between colon bacteria and epithelium, his colleague, Prof Samuel Huber from the University Medical Center Hamburg-Eppendorf, will focus on the relation between immune cells and epithelium. A better understanding of the different cell types responsible for tissue regeneration and immune responses could lead to the development of new therapies against chronic intestinal illnesses and colon cancer.

Till Strowig completed the Medical Biotechnology programme at the “Technische Universität” Berlin. He wrote his diploma thesis at the Rockefeller University in New York, where he later finished his PhD, funded by the Boehringer Ingelheim Foundation. Afterwards, Strowig continued his research at Yale University. Since June 2013, he is head of the junior research group Microbial Immune Regulation at the HZI.

The ERC Starting Grant is awarded annually by the European Research Council to outstanding talents from all scientific fields (http://erc.europa.eu/starting-grants). The main criterion for ERC funding is scientific excellence of the proposed research.

The “Microbial Immune Regulation” Junior Research Group investigates the functions of the microbiome and how it affects the development of infectious diseases.

The Helmholtz Centre for Infection Research
Scientists at the Helmholtz Centre for Infection Research in Braunschweig, Germany, are engaged in the study of different mechanisms of infection and of the body’s response to infection. Helping to improve the scientific community’s understanding of a given bacterium’s or virus’ pathogenicity is key to developing effective new treatments and vaccines.

http://www.helmholtz-hzi.de

Weitere Informationen:

http://www.helmholtz-hzi.de/en/news_events/news/view/article/complete/
eu_funds_research_project_on_intestinal_immune_processes/
- This press release on www.helmholtz-hzi.de

Dr. Ulrike Lampe | Helmholtz-Zentrum
Further information:
http://www.helmholtz-hzi.de

More articles from Awards Funding:

nachricht RNA: a vicious pathway to cancer ?
14.08.2017 | Goethe-Universität Frankfurt am Main

nachricht Extensive Funding for Research on Chromatin, Adrenal Gland, and Cancer Therapy
28.06.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Nagoya physicists resolve long-standing mystery of structure-less transition

21.08.2017 | Materials Sciences

Chronic stress induces fatal organ dysfunctions via a new neural circuit

21.08.2017 | Health and Medicine

Scientists from the MSU studied new liquid-crystalline photochrom

21.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>