Comparison of the virus strain with the sequences of other previously isolated strains showed that it originated in sub-Saharan Africa, rather than from vaccine strains or strains circulating in southern Europe.
In August 2006, the record temperatures experienced in northern Europe coincided with the first outbreak of BT in the Netherlands, Belgium, Luxemburg, and much of Germany. In the article Peter Mertens and 24 co-authors from six different institutes describe the sequence analysis of the full genome of this BTV strain and compare it to other BTV strains (Virology, doi:10.1016/j.virol.2008.04.028). Their results indicate that despite the high levels of nucleotide identity with other European strains, it represents a new strain introduction, originating from sub-Saharan Africa.
“Such timely and increasingly important insights into the origins of emerging viruses will lead not only to an increased understanding of how viruses like BTV spread, but also to rational vaccine development", said Barbara Sherry, one of the Editors of Virology.
Floris de Hon | alfa
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