Every year, 98 million male pigs are castrated in Europe and this surgery is usually carried out before the pigs are 14 days old. Castration is proven to be painful for these animals, not just during the course of the surgery itself, but also for several hours or days afterwards.
It is the treatment of this post-operative pain that Fosse has focused on in her thesis. In addition, piglets often experience pain in connection with conditions such as inflamed joints or traumatic injuries.
Fosse has studied the pharmacology of the two painkillers meloxicam and ketoprofen in piglets. She found that the piglets had a better ability to excrete ketoprofen when they were six days old than when they were three weeks old. This may mean that different dosages should be used, according to the age of the pigs being treated.
By means of an inflammatory model, Fosse showed that piglets treated with ketoprofen experienced significantly less pain when pressure was applied to the inflamed area than pigs receiving no treatment. The painkilling effect was evident for up to 24 hours after the treatment had been given. Meloxicam achieved only a low degree of painkilling effect in this model. Using another model, this medicine was also shown to have a low ability to prevent the production of inflammatory mediators in tissue.
The results of this doctorate can make a big difference to the choice of medicine and dosage to be used in the pain therapy of piglets up to a month old.
Veterinary surgeon Torunn Krangnes Fosse presented her doctoral thesis on 24th September 2010 at The Norwegian School of Veterinary Science. The thesis is entitled: ”Pharmacology of meloxicam and ketoprofen in piglets”.
Magnhild Jenssen | alfa
Energy crop production on conservation lands may not boost greenhouse gases
13.03.2017 | Penn State
How nature creates forest diversity
07.03.2017 | International Institute for Applied Systems Analysis (IIASA)
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy