Silver ions are very efficient at killing bacteria, and in contrast to antibiotic drugs they are effective against hundreds of different bacterial strains thanks to different attacking mechanisms.
This makes silver ideal as an antibacterial additive for, e.g., implants and wound dressings. The idea that “a little is good, more is better” cannot be adopted to silver in every case, since higher ion concentrations might also damage human cells and tissues. Therefore, surface coatings need to be made with a therapeutically useful range of silver.
One possible solution is offered by the novel nanostructured polymers with integrated silver nanoparticles which a team of Empa scientists led by Enrico Körner and Dirk Hegemann are developing within the frame of an EU Project called EMBEK1 (“polymer-based, multifunctional, bactericidal materials”). In the context of this research work they investigate how varying plasma conditions during deposition influence the film structure and the associated silver ion release that determines the antibacterial effectiveness. The researchers have determined the basics for “designing” tailor-made coatings with desirable properties. The results of this work have recently been published in the scientific journal “Plasma Processes and Polymers”.
Silver nanoparticles are firmly incorporated in the plasma layer
The Empa team used a so-called RF Plasma Reactor, in which hydrocarbon coatings can be deposited on different substrates. As raw materials a hydrocarbon gas such as ethylene (C2H4) is mixed with a reactive gas such as carbon dioxide (CO2) in order to obtain a cross-linked plasma polymer matrix containing functional groups required for cell growth. The electrical energy necessary to drive this process is supplied by electrodes. In order to incorporate silver particles firmly in the plasma layer, one of the electrodes is made of pure silver where a high voltage has to be applied for sputtering conditions. Nevertheless, the film deposition occurs near room temperature allowing the treatment of temperature-sensitive materials.
These results can be used to transfer the deposition process from the laboratory scale to Empa’s in-house pilot plant, the first step towards industrial production of the tailor-made antibacterial coatings. In addition, the research team is attempting to create coatings with gradients in the silver concentration enabling the controlled release of silver ions over a certain time period. A polymer covering layer would thereby help human cells to grow optimally on the antibacterial coating.Literature
Beatrice Huber | idw
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