Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug patch treatment sees new breakthrough

09.09.2013
An assistant professor with the Virginia Tech - Wake Forest School of Biomedical Engineering has developed a flexible microneedle patch that allows drugs to be delivered directly and fully through the skin.

The new patch can quicken drug delivery time while cutting waste, and can likely minimize side-effects in some cases, notable in vaccinations and cancer therapy.

News of the delivery technology was published in a recent issue of the scientific journal, Advanced Materials.

Leading development of the flexible patch was Lissett Bickford, now an assistant professor and researcher of biomedical engineering and the mechanical engineering, both part of the Virginia Tech College of Engineering. Work on the technology was completed while Bickford was a post-doctoral research associate at the University of North Carolina Chapel Hill.

Microneedle patch technology used on the skin has existed for several years, each patch containing an array of hundreds of micron-sized needles that pierce the skin and dissolve, delivering embedded therapeutics. However, because of their rigid chemical makeup, the patches proved difficult in fully piercing into the skin, creating a waste of drug material and a slowed delivery time. Additionally, the patches also have been difficult to produce in bulk; typical fabrication procedures have required centrifugation.

Bickford, with her research team, including Chapel Hill graduate student Katherine A. Moga, were able to develop a new flexible microneedle patch that forms to the skin directly – think a regular household bandage – and then fully pierces the skin and dissolves. Bickford said the softer, more malleable and water-soluble material also allows for more precise control over the shape, size, and composition of the patch, with little to no waste.

The nanoparticle, micro-molding patch is based on Particle Replication In Non-wetting Templates (PRINT for short) technology, developed by University of North Carolina researcher and professor Joseph DeSimone. Unlike other methods for making these patches, the new technology allows for quicker and greater wide-scale production, reducing related costs.

Research and work on the new patch was funded by the National Institutes of Health and Chapel Hill's University Cancer Research Fund. Advanced Materials wrote of the breakthrough in its July issue.

Bickford earned her bachelor's degree in mechanical engineering from Texas A&M University in 1998, followed by a master's degree in biomedical engineering from The University of Texas Austin inn 2001; and a doctoral degree in bioengineering from Rice University in 2010.

At Virginia Tech, she is director and principal investigator of the Translational Oncology & Nano/Pharmacoengineering Laboratory where she focuses on the development of cost-effective tools for cancer diagnosis and treatment.

Steven Mackay | EurekAlert!
Further information:
http://www.vt.edu

More articles from Materials Sciences:

nachricht Let the good tubes roll
19.01.2018 | DOE/Pacific Northwest National Laboratory

nachricht Method uses DNA, nanoparticles and lithography to make optically active structures
19.01.2018 | Northwestern University

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>