Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A rapid, paper-based diagnostic test for tuberculosis

07.10.2013
In a study published in the journal Science and Technology of Advanced Materials (STAM), researchers in Taiwan describe a simple, color-based diagnostic approach with the potential to detect target DNA sequences found in TB-causing mycobacteria – in just a fraction of the time required for established diagnostic tests.

More than a century after the identification of organisms that cause tuberculosis (TB), this disease remains a global public health challenge. According to World Health Organization estimates, there were 8.7 million new cases in 2011 and 1.4 million deaths. Most new cases occur in developing countries that lack the facilities and trained personnel required for early detection of TB.

In a new study, published in the journal Science and Technology of Advanced Materials (STAM), researchers in Taiwan describe a simple, color-based diagnostic approach with the potential to detect target DNA sequences found in TB-causing mycobacteria – in just a fraction of the time required for established diagnostic tests.

The standard method for TB detection in a clinical setting involves culturing the Mycobacterium tuberculosis bacillus, which requires 3-6 weeks to grow on solid culture media or 9-16 days in rapid liquid culture media. A faster alternative is the polymerase chain reaction (PCR) technology. However, it is still too slow (turnaround time 2-5 hours) and requires sophisticated infrastructure and trained personnel that might be unavailable in developing countries.

In their STAM paper, Tsung-Ting Tsai and colleagues employed gold nanoparticles and microfluidic paper-based analytical devices to achieve rapid diagnosis without the need for complex and time-consuming laboratory processes. They easily detected TB mycobacterium target sequences, and the turnaround time was approximately 1 hour after the human DNA was extracted from patients.

Although the authors are still optimizing their technology, they already believe that it will result in “affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and highly end-user-deliverable diagnostic applications”.

For more information about this research, please contact:

Media contacts:
National Institute for Materials Science, Tsukuba, Japan
Email: stam_office@nims.go.jp
Tel. +81-(0)29-859-2494

Journal information
[1] Tsung-Ting Tsai et al, Paper-based tuberculosis diagnostic devices with colorimetric gold nanoparticles, Sci. Technol. Adv. Mater. 14 (2013) 044404

Mikiko Tanifuji | Research asia research news
Further information:
http://www.nims.go.jp
http://www.researchsea.com

More articles from Materials Sciences:

nachricht An innovative high-performance material: biofibers made from green lacewing silk
20.01.2017 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

nachricht Treated carbon pulls radioactive elements from water
20.01.2017 | Rice University

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>