The first clinical trial to compare directly two of the most widely-used drugs in advanced lung cancer, cisplatinin and carboplatin (both in combination with paclitaxel) – have concluded that the older drug, cisplatin, is the better treatment.

Patients given cisplatin and paclitaxel had better survival rates and their quality of life was just as good as patients receiving carboplatin and paclitaxel.

The phase III multi-national European trial involving 618 patients with advanced non

A research team at two Midwest universities has developed a new way to genetically alter cells in living mice, offering new possibilities in the war against cancer and other diseases.

Using a modified virus as a Trojan horse, a team led by Purdue University’s David Sanders has found a promising system to deliver genes to diseased liver and brain cells. By placing helpful genetic material within the outer protein shell of Ross River Virus (RRV), Sanders’ team was able to alter the

Companies that create HIV-AIDS drugs now have key information that could assist in making new medications with fewer side effects.

Researchers Henry Weiner, a professor of biochemistry at Purdue University, Steven Zollo of the National Institute of Standards and Technology and Lauren Wood of the National Cancer Institute, noted the similarity between HIV-AIDS treatment side effects and naturally occurring diseases. Certain HIV-AIDS treatment side effects, such as fat loss and insulin resista

A team led by Terumi Kohwi-Shigematsu of Lawrence Berkeley National Laboratory’s Life Sciences Division has demonstrated that SATB1, a protein crucial to the development of the immune system, works by forming a network in the cell nucleus, attaching chromatin to the network structure at specific sites, and orchestrating remodeling of the chromatin over long distances to regulate gene expression.

“SATB1 determines when and how the genes are read — when they are activated and when they are

Using an optical fluorescence microscope to monitor enzyme activity, researchers at three universities have solved a long-running mystery. It takes at least two proteins, working in an unstable tandem, to unzip two strands of DNA.

Their newly designed approach, which focuses on the activity of single molecules, also showed — for the first time — that if one protein falls away, the process stops. Unless another climbs aboard, DNA reverts to its zipped state.

The technique, which o

Ribosome Recycling Factor Mimics Shape, But Not The Functions of Transfer RNA
RRF Protein Offers Potential Target for New Antibiotics

The fact that ribosome recycling factor (RRF) looks a lot like transfer RNA (tRNA) has not been lost on scientists. After all, both molecules are an important part of a bacteria’s ability to create new proteins. Researchers at the University of Pennsylvania School of Medicine and the University of Southern California, Santa Cruz, however, hav