Life Sciences and Chemistry

The gold-loving king’s rich diet may have hastened his decay.

Legend says that lust for gold was the cause of King Midas’ downfall. But his appetite for meat may have destroyed the final monument to his greatness 1 .

A mound excavated 44 years ago in Turkey is thought to be the resting place of the eighth-century BC ruler of Phrygia. The large tomb, although built of durable cedar wood, is in surprisingly bad shape, says geophysicist Timothy Filley of the Car

Researchers discover two molecules that help fruitflies sleep.

Mutant flies that lack the chemicals sleep more. In mammals the same molecules are also involved in learning and memory, supporting the idea that one function of sleep is to consolidate our record of the day’s experiences 1 .

The molecules are cyclic AMP and CREB, chemical messengers that work within cells. Cyclic AMP activates CREB, which then switches on genes.

Joan Hendricks, of th

Two techniques may help deduce proteins’ functions.

Imagine trying to guess what machines do just be looking at them. Even a can-opener would pose problems, if you didn’t know about cans. This is the challenge that faces molecular biologists as they try to make sense of protein molecules in the cell.

Two new techniques may help. One deduces a protein’s function from its shape; the other deduces its shape from a list of component parts 1 , 2 .

ATTO-TEC® has developed the second generation of fluorescent dyes which are stable at room temperature for more than six months.

With Atto 520, Atto 565 and Atto 590 we are pleased to offer three stable fluorescent dyes as amine-reactive succinimidyl esters which will be available from November 2001 on. This allows researchers an easy handling for selectively target- labeling by linking a fluorophore to primary amine groups on proteins or modified nucleic acids.
Further stable activate

Chemists build molecules by paring them down

Complex molecules, such as many drugs, can be fiddly to assemble. By binding their starting compounds in chains 1 , chemists in Denmark may have found a way speed the automated chemical synthesis of such complicated products.

Les Miranda and Morten Meldal of Carlsberg University in Copenhagen have solved the following problem. Complex molecules are usually built up from a core with several near-identical hooks on w

Chameleons can reel in prey anywhere within two-and-a-half body lengths of their jaws. Their tongues can overcome even a bird’s weight and reluctance to be eaten. How? Muscles that are unique among backboned animals, researchers now reveal.

Anthony Herrel of the University of Antwerp, Belgium, and colleagues put crickets at different distances from the noses of two chameleon species, Chameleo calyptratus and Chameleo oustaletti. The tongues of these 12-cm-long reptiles pull at maximum stren