Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

German scientists advance light microscopy

21.10.2008
Although more than 400 years old, optical microscopy is still one of the most important methods used in medical research and biology.

Its potential, however, could still increase significantly due to an invention recently made by a team of interdisciplinary working physicists.

Published as cover story in the current issue of the open access Journal "Optics Express", the researchers from Prof. Käs' group in Leipzig, in collaboration with researchers in Jena and Cambridge present the Optical Cell Rotator (OCR), a novel tool for the contact-free orientation of biological samples using laser radiation.

According to first author Moritz Kreysing the new technology could be the missing key to allow for the realization of single-cell optical tomography, which has been shown in principle but not in any useful implementation.

In contrast to the current standards for 3D imaging of cells, namely confocal and deconvolution microscopy, tomographic imaging provides maximum resolution in all three dimensions. To achieve this feat specimens are rotated stepwise and imaged from multiple angles. Using this data a computer is able to reconstruct a three-dimensional model of the sample containing 2.5 times more information than traditionally accessible.

The Optical Cell Rotator is of fundamental importance in this context for the integrity of living samples. While the orientation of cells previously required their exposure to either strong electric fields or unphysiological mechanical tools, the new device promises a much more gentle handling of the sensitive material. Thus, OCR is probably most useful for the investigation of stem cells, which are notoriously sensitive to handling.

http://www.opticsinfobase.org/oe/viewmedia.cfm?uri=oe-16-21-16984&seq=0
Abstract: http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-21-16984
On the cover: http://www.opticsinfobase.org/oe/issue.cfm?volume=16&issue=21
Publication supplements:
1: http://www.opticsinfobase.org/oe/viewmedia.cfm?uri=oe-16-21-16984&seq=1
2: http://www.opticsinfobase.org/oe/viewmedia.cfm?uri=oe-16-21-16984&seq=2
Weitere Informationen:
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-21-16984
http://www.opticsinfobase.org/oe/issue.cfm?volume=16&issue=21

Dr. Bärbel Adams | idw
Further information:
http://www.uni-leipzig.de

More articles from Physics and Astronomy:

nachricht Electronic evidence of non-Fermi liquid behaviors in an iron-based superconductor
11.12.2018 | Science China Press

nachricht Physicists edge closer to controlling chemical reactions
11.12.2018 | Moscow Institute of Physics and Technology

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

 
Latest News

Electronic evidence of non-Fermi liquid behaviors in an iron-based superconductor

11.12.2018 | Physics and Astronomy

Topological material switched off and on for the first time

11.12.2018 | Materials Sciences

NIST's antenna evaluation method could help boost 5G network capacity and cut costs

11.12.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>