St. Michael's Hospital today became the first in North America to use a novel blood-cleaning procedure for a kidney patient that will allow him to receive a transplant from a donor with a different blood type.
Transplants involving a donor and recipient with different blood types are rare. Most people have natural antibodies in their blood that would cause their immune system to reject an organ from someone with a different blood type.
The procedure used today is called plasmapheresis and is similar to kidney dialysis, which removes waste products from the blood. Plasmapheresis separates plasma from patient's blood, and runs it through a column-shaped device containing synthetic carbohydrate beads that trap the blood group antibodies. The "washed" plasma is then returned to the patient's body.
Andre Cossette, a Grade 4 teacher at Ange-Gabriel Elementary Catholic School in Mississauga, Ont., has been on dialysis for three years. He is scheduled to receive a kidney transplant from his brother, who has Type AB blood, on Aug. 11. Cossette has Type A blood and antibodies against Type B.
"If this procedure works, I get to get my brother's kidney," Cossette said, shortly after beginning the procedure, which was expected to last two to four hours. "I won't have to be on a waiting list, waiting for a call to come to the hospital within four hours because there may be a kidney available."
The procedure may need to be repeated a few times to get rid of all the antibodies. The patient will also receive medications to prevent his immune system from making more antibodies and attacking the transplanted kidney.
Dr. Jeff Zaltzman, director of the hospital's kidney transplant program, said the procedure could expand the number of living organ donors. More than one-third of potential live donors are turned down because their blood types are not compatible with the person to whom they wish to donate their kidney.
"Every time you have a living donor, you're helping someone who would otherwise be on a transplant waiting list for a long time," Dr. Zaltzman said. "That's also one more person who is not taking an organ from a deceased donor, which could then be given to someone else."
In Ontario, 1,075 people are on a waiting list for a kidney transplant, according to the Trillium Gift of Life Network, the province's organ and tissue donation agency.
The device used today at St. Michael's, known as the Glycosorb ABO, was developed by Glycorex Transplantation, a Swedish company, and approved by Health Canada last year. It has been used once in Canada for a recent heart transplant in Alberta, but this is the first time for a kidney patient. The device is used in 21 countries, mainly in Europe, for kidney, liver, heart, lung and stem cell transplants.
About St. Michael's Hospital
St. Michael's Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future health care professionals in more than 23 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, and care of the homeless are among the Hospital's recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Center, which make up the Li Ka Shing Knowledge Institute, research and education at St. Michael's Hospital are recognized and make an impact around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto.
For more information please contact:Leslie Shepherd
Leslie Shepherd | EurekAlert!
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
16.08.2018 | Information Technology
16.08.2018 | Health and Medicine
16.08.2018 | Information Technology