Millions of people the world over suffer today from obesity, yet there is no “magic bullet” that has yet provided a universally accepted solution. However, a young researcher at the Hebrew University of Jerusalem feels he has come up with a practical weight loss solution for the obese person without his having to feel hungry.
For this development, Yaniv Linde, a 32-year-old Ph.D. student of Prof. Chaim Gilon in the Department of Organic Chemistry at the Hebrew University, has been named a first place winner of a Kaye Innovation Award, which was presented today (June 6) during the 70th meeting of the Hebrew University Board of Governors.
Linde and his associates have developed a compound that mimics the activity of the naturally occurring hormone called aMSH. This hormone is naturally excreted during eating and binds to a receptor in the brain called MC4R. When this “communication” occurs on a substantial level, the brain sends out a signal that one feels “full.”
The young Hebrew university researchers developed a novel method for synthesizing a peptide (a peptide is a compound linking two or more amino acids) which can serve as an analog to the naturally occurring aMSH hormone. They were able to demonstrate that their peptide, which they call BL-3020, displayed good metabolic stability to intestinal enzymes when swallowed, and that it was able to cross the intestinal wall and gain access into the blood stream. Once in the blood, it could make its way to the MC4R receptor and “close the circuit” to send out the “full” signal.
The result is that a person seriously wishing to overcome obesity could take this compound orally in order to curb his appetite, thus leading to natural weight loss. In experiments with mice, it was shown that a single oral administration of BL-3020 led to reduced consumption over a period of 24 hours. Over a 12-day period of daily dosages, the mice weighed 40 percent less than the average for mice of their size and age who were not being given the compound.
The peptide has been patented in Europe and the U.S., and a commercial firm, Bioline RX Ltd. of Jerusalem has purchased development rights from Yissum, the Hebrew University’s technology transfer company, and is currently working towards creating a commercial anti-obesity drug.
The Kaye Innovation Awards at the Hebrew University have been awarded annually since 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff, and students of the Hebrew University to develop innovative methods and inventions with good commercial potential which will benefit the university and society.
Jerry Barach | alfa
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences